biostudies-literatureUnknown41Pande SCytomegalovirus (CMV) is the most common cause of congenital viral infections. Women seropositive for CMV prior to pregnancy can develop a non-primary CMV infection. Here, we present a case of first trimester pregnancy loss during active SARS-CoV-2 infection. There was no evidence of SARS-CoV-2 RNA in placenta and fetal tissue, but there was presence of congenital cytomegalovirus infection by nested PCR. To the best of our knowledge, this is the first report demonstrating association of early congenital CMV infection due to reactivation and fetal demise in a SARS-CoV-2 positive woman with fetal trisomy 21.Indian journal of medical microbiology1-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780583biostudies-literatureCytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report.PMC9780583Munne KPalav HGaikwad PSachdeva GPande SBhase MBhagat SBashani DPatel VBhor VMShah KShende PGandhewar MMenon SDas DRathore AGawde HPadwal VfalseCytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report.Cytomegalovirus (CMV) is the most common cause of congenital viral infections. Women seropositive for CMV prior to pregnancy can develop a non-primary CMV infection. Here, we present a case of first trimester pregnancy loss during active SARS-CoV-2 infection. There was no evidence of SARS-CoV-2 RNA in placenta and fetal tissue, but there was presence of congenital cytomegalovirus infection by nested PCR. To the best of our knowledge, this is the first report demonstrating association of early congenital CMV infection due to reactivation and fetal demise in a SARS-CoV-2 positive woman with fetal trisomy 21.2023-01-01T00:00:00Z2023 Jan-Feb2025-04-04T11:35:18.747Z2025-04-04T11:35:18.747ZS-EPMC97805833687074010.1016/j.ijmmb.2022.12.002