{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie Y"],"funding":["Guangzhou Science and Technology Plan Project","China Postdoctoral Science Foundation Special Funded Project","National Natural Science Foundation of China"],"pagination":["15850"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781137"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(24)"],"pubmed_abstract":["As one of the most studied mesoporous silica nanoparticles (MSNs) in drug delivery systems, Mobil Composition of Matter No. 41 (MCM-41) possesses unique properties including perfect channel architecture, excellent load capacity, and good biocompatibility. However, the applications of MCM-41 nanoparticles in drug delivery have not yet been industrialized, due to the interaction between MCM-41 and biomolecules (especially proteins) that affect their in vivo behaviors after dosing. To investigate the interactions between MCM-41 and proteins, this study selected bovine serum albumin (BSA), lysozyme (Lyso), and bovine hemoglobin (BHb) as model proteins and characterized the ultraviolet-visible, fluorescence, circular dichroism spectra and the protein adsorption of MCM-41-protein complex. The UV"],"journal":["International journal of molecular sciences"],"pubmed_title":["Three Different Interaction Patterns between MCM-41 and Proteins."],"pmcid":["PMC9781137"],"funding_grant_id":["202201010589","2022T150268","82104070"],"pubmed_authors":["Pan X","Xie Y","Huang Y","Huang Z","Wu C","Wang W","Zhong Z"],"additional_accession":[]},"is_claimable":false,"name":"Three Different Interaction Patterns between MCM-41 and Proteins.","description":"As one of the most studied mesoporous silica nanoparticles (MSNs) in drug delivery systems, Mobil Composition of Matter No. 41 (MCM-41) possesses unique properties including perfect channel architecture, excellent load capacity, and good biocompatibility. However, the applications of MCM-41 nanoparticles in drug delivery have not yet been industrialized, due to the interaction between MCM-41 and biomolecules (especially proteins) that affect their in vivo behaviors after dosing. To investigate the interactions between MCM-41 and proteins, this study selected bovine serum albumin (BSA), lysozyme (Lyso), and bovine hemoglobin (BHb) as model proteins and characterized the ultraviolet-visible, fluorescence, circular dichroism spectra and the protein adsorption of MCM-41-protein complex. The UV","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:07.501Z","creation":"2025-04-04T08:00:07.501Z"},"accession":"S-EPMC9781137","cross_references":{"pubmed":["36555490"],"doi":["10.3390/ijms232415850"]}}