biostudies-literatureXie YGuangzhou Science and Technology Plan ProjectChina Postdoctoral Science Foundation Special Funded ProjectNational Natural Science Foundation of China15850https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781137biostudies-literatureUnknown23(24)As one of the most studied mesoporous silica nanoparticles (MSNs) in drug delivery systems, Mobil Composition of Matter No. 41 (MCM-41) possesses unique properties including perfect channel architecture, excellent load capacity, and good biocompatibility. However, the applications of MCM-41 nanoparticles in drug delivery have not yet been industrialized, due to the interaction between MCM-41 and biomolecules (especially proteins) that affect their in vivo behaviors after dosing. To investigate the interactions between MCM-41 and proteins, this study selected bovine serum albumin (BSA), lysozyme (Lyso), and bovine hemoglobin (BHb) as model proteins and characterized the ultraviolet-visible, fluorescence, circular dichroism spectra and the protein adsorption of MCM-41-protein complex. The UVInternational journal of molecular sciencesThree Different Interaction Patterns between MCM-41 and Proteins.PMC97811372022010105892022T15026882104070Pan XXie YHuang YHuang ZWu CWang WZhong ZfalseThree Different Interaction Patterns between MCM-41 and Proteins.As one of the most studied mesoporous silica nanoparticles (MSNs) in drug delivery systems, Mobil Composition of Matter No. 41 (MCM-41) possesses unique properties including perfect channel architecture, excellent load capacity, and good biocompatibility. However, the applications of MCM-41 nanoparticles in drug delivery have not yet been industrialized, due to the interaction between MCM-41 and biomolecules (especially proteins) that affect their in vivo behaviors after dosing. To investigate the interactions between MCM-41 and proteins, this study selected bovine serum albumin (BSA), lysozyme (Lyso), and bovine hemoglobin (BHb) as model proteins and characterized the ultraviolet-visible, fluorescence, circular dichroism spectra and the protein adsorption of MCM-41-protein complex. The UV2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:07.501Z2025-04-04T08:00:07.501ZS-EPMC97811373655549010.3390/ijms232415850