biostudies-literaturede Sales ROSão Paulo Research FoundationCAPES fellowshipFundaçao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE)1394https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781218biostudies-literatureUnknown11(12)<i>Klebsiella pneumoniae</i> is considered an opportunistic pathogen frequently involved with healthcare-associated infections. The genome of <i>K. pneumoniae</i> is versatile, harbors diverse virulence factors and easily acquires and exchanges resistance plasmids, facilitating the emergence of new threatening clones. In the last years, ST16 has been described as an emergent, clinically relevant strain, increasingly associated with outbreaks, and carrying virulence factors (such as ICE<i>Kp</i>, <i>iuc</i>, <i>rmpADC/2</i>) and a diversity of resistance genes. However, a far-reaching phylogenetic study of ST16, including geographically, clinically and temporally distributed isolates is not available. In this work, we analyzed all publicly available ST16 <i>K. pneumoniae</i> genomes in termPathogens (Basel, Switzerland)A Comprehensive Genomic Analysis of the Emergent <i>Klebsiella pneumoniae</i> ST16 Lineage: Virulence, Antimicrobial Resistance and a Comparison with the Clinically Relevant ST11 Strain.PMC9781218FAPESP 2018/19243-42018/19243-4FAPESP 2022/03596-02022/03596-0Leaden LMigliorini LBde Sales ROSeverino PfalseA Comprehensive Genomic Analysis of the Emergent <i>Klebsiella pneumoniae</i> ST16 Lineage: Virulence, Antimicrobial Resistance and a Comparison with the Clinically Relevant ST11 Strain.<i>Klebsiella pneumoniae</i> is considered an opportunistic pathogen frequently involved with healthcare-associated infections. The genome of <i>K. pneumoniae</i> is versatile, harbors diverse virulence factors and easily acquires and exchanges resistance plasmids, facilitating the emergence of new threatening clones. In the last years, ST16 has been described as an emergent, clinically relevant strain, increasingly associated with outbreaks, and carrying virulence factors (such as ICE<i>Kp</i>, <i>iuc</i>, <i>rmpADC/2</i>) and a diversity of resistance genes. However, a far-reaching phylogenetic study of ST16, including geographically, clinically and temporally distributed isolates is not available. In this work, we analyzed all publicly available ST16 <i>K. pneumoniae</i> genomes in term2022-01-01T00:00:00Z2022 Nov2026-05-08T03:16:52.199Z2025-02-19T03:01:42.648ZS-EPMC97812183655872910.3390/pathogens11121394