{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(24)"],"submitter":["Ali SG"],"pubmed_abstract":["Antimicrobial resistance has posed a serious health concern worldwide, which is mainly due to the excessive use of antibiotics. In this study, gold nanoparticles synthesized from the plant <i>Tinospora cordifolia</i> were used against multidrug-resistant <i>Pseudomonas aeruginosa</i>. The active components involved in the reduction and stabilization of gold nanoparticles were revealed by gas chromatography-mass spectrophotometry(GC-MS) of the stem extract of <i>Tinospora cordifolia.</i> Gold nanoparticles (TG-AuNPs) were effective against <i>P. aeruginosa</i> at different concentrations (50,100, and 150 µg/mL). TG-AuNPs effectively reduced the pyocyanin level by 63.1% in PAO1 and by 68.7% in clinical isolates at 150 µg/mL; similarly, swarming and swimming motilities decreased by 53.1% and "],"journal":["Molecules (Basel, Switzerland)"],"pagination":["8685"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781250"],"repository":["biostudies-literature"],"pubmed_title":["Biosynthesis of Gold Nanoparticles and Its Effect against <i>Pseudomonas aeruginosa</i>."],"pmcid":["PMC9781250"],"pubmed_authors":["Ahmad A","Alshammari MB","Ali SG","Ahmad H","Umar K","Jalal M","Khan HM"],"additional_accession":[]},"is_claimable":false,"name":"Biosynthesis of Gold Nanoparticles and Its Effect against <i>Pseudomonas aeruginosa</i>.","description":"Antimicrobial resistance has posed a serious health concern worldwide, which is mainly due to the excessive use of antibiotics. In this study, gold nanoparticles synthesized from the plant <i>Tinospora cordifolia</i> were used against multidrug-resistant <i>Pseudomonas aeruginosa</i>. The active components involved in the reduction and stabilization of gold nanoparticles were revealed by gas chromatography-mass spectrophotometry(GC-MS) of the stem extract of <i>Tinospora cordifolia.</i> Gold nanoparticles (TG-AuNPs) were effective against <i>P. aeruginosa</i> at different concentrations (50,100, and 150 µg/mL). TG-AuNPs effectively reduced the pyocyanin level by 63.1% in PAO1 and by 68.7% in clinical isolates at 150 µg/mL; similarly, swarming and swimming motilities decreased by 53.1% and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T07:59:17.888Z","creation":"2025-04-04T07:59:17.888Z"},"accession":"S-EPMC9781250","cross_references":{"pubmed":["36557818"],"doi":["10.3390/molecules27248685"]}}