biostudies-literatureUnknown14(12)Camargo MThe cervical microbiota is essential in female sexual health, and its altered states seem to have a central role in the dynamic of high-risk papillomavirus (hrHPV) infections. This study aimed to evaluate the variation in bacterial communities' compositions according to hrHPV. We collected two samples per woman, with a difference of 12 ± 1 months between them, and performed a follow-up on 66 of these women. The viral load (VL) of the hrHPV was estimated by quantitative PCR (qPCR), then it was normalized (using the <i>HMBS</i> gene as reference) and transformed to the Log₁₀ scale to facilitate the interpretation. The VL was categorized as Negative, without hrHPV copies; Low, less than 10⁰ hrHPV copies; Medium, between 10⁰ to 10² hrHPV copies; and Viruses2674https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781391biostudies-literatureChanges in the Cervical Microbiota of Women with Different High-Risk Human Papillomavirus Loads.PMC9781391Patarroyo MESanchez RVega LMunoz MCamargo MRamirez JDPatarroyo MAfalseChanges in the Cervical Microbiota of Women with Different High-Risk Human Papillomavirus Loads.The cervical microbiota is essential in female sexual health, and its altered states seem to have a central role in the dynamic of high-risk papillomavirus (hrHPV) infections. This study aimed to evaluate the variation in bacterial communities' compositions according to hrHPV. We collected two samples per woman, with a difference of 12 ± 1 months between them, and performed a follow-up on 66 of these women. The viral load (VL) of the hrHPV was estimated by quantitative PCR (qPCR), then it was normalized (using the <i>HMBS</i> gene as reference) and transformed to the Log₁₀ scale to facilitate the interpretation. The VL was categorized as Negative, without hrHPV copies; Low, less than 10⁰ hrHPV copies; Medium, between 10⁰ to 10² hrHPV copies; and 2022-01-01T00:00:00Z2022 Nov2026-04-08T10:56:48.204Z2024-11-15T17:28:06.469ZS-EPMC97813913656067810.3390/v14122674