biostudies-literatureCastro JGeneralitat de Catalunya, DGUUniversitat de GironaMinisterio de Economia y Competitividad (MINECO) Spain2801https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781652biostudies-literatureUnknown14(12)A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC₅₀ values 2-6 fold lower than that of cisplatin, and 30-90 fold lower than that of carboplatin for the tumor cell lines assayed. Comparing the IC₅₀ values between tumor and non-tumor cell lines, the selectivity indexes range from 3.2 to 34, compound <b>10, [Fe₂(4)₂(CH₃CN)₄](BF₄)₄</b>, showing the highest selectivity. Those compounds carrying substituents on the iminopyridine ring show the same cytotoxicity as those without substituents. However, the electronic effects of the substituents on position 6 may be important for the cytotoxicity of thePharmaceuticsDinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration.PMC9781652BIO2013-43517SGR2014-70 and 2017 SGR 1720MPCUdG2016-18 and MPCUdG2016/048Marsal AVilanova MAlonso-De Gennaro MJRomero ICastro JBravo MClaver CBenito AMartinez-Ferrate OAlberti Mvan Leeuwen PWNMfalseDinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration.A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC₅₀ values 2-6 fold lower than that of cisplatin, and 30-90 fold lower than that of carboplatin for the tumor cell lines assayed. Comparing the IC₅₀ values between tumor and non-tumor cell lines, the selectivity indexes range from 3.2 to 34, compound <b>10, [Fe₂(4)₂(CH₃CN)₄](BF₄)₄</b>, showing the highest selectivity. Those compounds carrying substituents on the iminopyridine ring show the same cytotoxicity as those without substituents. However, the electronic effects of the substituents on position 6 may be important for the cytotoxicity of the2022-01-01T00:00:00Z2022 Dec2025-04-22T13:18:26.938Z2025-04-06T00:38:09.742ZS-EPMC97816523655929410.3390/pharmaceutics14122801