{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(24)"],"submitter":["Yang T"],"pubmed_abstract":["2-oxazolines are common moieties in numerous natural products, pharmaceuticals, and functional copolymers. Current methods for synthesizing 2-oxazolines mainly rely on stoichiometric dehydration agents or catalytic dehydration promoted by specific catalysts. These conditions either generate stoichiometric amounts of waste or require forcing azeotropic reflux conditions. As such, a practical and robust method that promotes dehydrative cyclization while generating no byproducts would be attractive to oxazoline production. Herein, we report a triflic acid (TfOH)-promoted dehydrative cyclization of <i>N</i>-(2-hydroxyethyl)amides for synthesizing 2-oxazolines. This reaction tolerates various functional groups and generates water as the only byproduct. This method affords oxazoline with inversi"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["9042"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781752"],"repository":["biostudies-literature"],"pubmed_title":["A Facile Synthesis of 2-Oxazolines via Dehydrative Cyclization Promoted by Triflic Acid."],"pmcid":["PMC9781752"],"pubmed_authors":["Huang C","Ni F","Yang T","Wu F","Jia J"],"additional_accession":[]},"is_claimable":false,"name":"A Facile Synthesis of 2-Oxazolines via Dehydrative Cyclization Promoted by Triflic Acid.","description":"2-oxazolines are common moieties in numerous natural products, pharmaceuticals, and functional copolymers. Current methods for synthesizing 2-oxazolines mainly rely on stoichiometric dehydration agents or catalytic dehydration promoted by specific catalysts. These conditions either generate stoichiometric amounts of waste or require forcing azeotropic reflux conditions. As such, a practical and robust method that promotes dehydrative cyclization while generating no byproducts would be attractive to oxazoline production. Herein, we report a triflic acid (TfOH)-promoted dehydrative cyclization of <i>N</i>-(2-hydroxyethyl)amides for synthesizing 2-oxazolines. This reaction tolerates various functional groups and generates water as the only byproduct. This method affords oxazoline with inversi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T16:00:30.124Z","creation":"2025-04-07T02:57:31.416Z"},"accession":"S-EPMC9781752","cross_references":{"pubmed":["36558175"],"doi":["10.3390/molecules27249042"]}}