biostudies-literatureUnknown27(24)Yang T2-oxazolines are common moieties in numerous natural products, pharmaceuticals, and functional copolymers. Current methods for synthesizing 2-oxazolines mainly rely on stoichiometric dehydration agents or catalytic dehydration promoted by specific catalysts. These conditions either generate stoichiometric amounts of waste or require forcing azeotropic reflux conditions. As such, a practical and robust method that promotes dehydrative cyclization while generating no byproducts would be attractive to oxazoline production. Herein, we report a triflic acid (TfOH)-promoted dehydrative cyclization of <i>N</i>-(2-hydroxyethyl)amides for synthesizing 2-oxazolines. This reaction tolerates various functional groups and generates water as the only byproduct. This method affords oxazoline with inversiMolecules (Basel, Switzerland)9042https://www.ebi.ac.uk/biostudies/studies/S-EPMC9781752biostudies-literatureA Facile Synthesis of 2-Oxazolines via Dehydrative Cyclization Promoted by Triflic Acid.PMC9781752Huang CNi FYang TWu FJia JfalseA Facile Synthesis of 2-Oxazolines via Dehydrative Cyclization Promoted by Triflic Acid.2-oxazolines are common moieties in numerous natural products, pharmaceuticals, and functional copolymers. Current methods for synthesizing 2-oxazolines mainly rely on stoichiometric dehydration agents or catalytic dehydration promoted by specific catalysts. These conditions either generate stoichiometric amounts of waste or require forcing azeotropic reflux conditions. As such, a practical and robust method that promotes dehydrative cyclization while generating no byproducts would be attractive to oxazoline production. Herein, we report a triflic acid (TfOH)-promoted dehydrative cyclization of <i>N</i>-(2-hydroxyethyl)amides for synthesizing 2-oxazolines. This reaction tolerates various functional groups and generates water as the only byproduct. This method affords oxazoline with inversi2022-01-01T00:00:00Z2022 Dec2025-04-18T16:00:30.124Z2025-04-07T02:57:31.416ZS-EPMC97817523655817510.3390/molecules27249042