{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Caliskan R"],"funding":["Istanbul Aydin University Scientific Research Projects Unit"],"pagination":["1738"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(12)"],"pubmed_abstract":["<i>Background and Objectives</i>: <i>Helicobacter pylori</i> infection is associated with chronic gastritis, ulcers, and gastric cancer. The <i>H. pylori</i> Type 4 secretion system (T4SS) translocates the CagA protein into host cells and plays an essential role in initiating gastric carcinogenesis. The CagL protein is a component of the T4SS. CagL amino acid polymorphisms are correlated with clinical outcomes. We aimed to study the association between CagL amino acid polymorphisms and peptic ulcer disease (PUD) and non-ulcer dyspepsia (NUD). <i>Materials and Methods</i>: A total of 99 patients (PUD, 46; NUD, 53) were enrolled and screened for <i>H. pylori</i> by qPCR from antrum biopsy samples. The amino acid polymorphisms of CagL were analyzed using DNA sequencing, followed by the MAFFT "],"journal":["Medicina (Kaunas, Lithuania)"],"pubmed_title":["New CagL Amino Acid Polymorphism Patterns of <i>Helicobacter pylori</i> in Peptic Ulcer and Non-Ulcer Dyspepsia."],"pmcid":["PMC9782086"],"funding_grant_id":["2018/05"],"pubmed_authors":["Caliskan R","Ercan B","Omac Sonmez M","Oner YA","Yuksel Mayda P","Peker KD","Sapmaz B","Soylu A","Polat Sari S","Adas GT","Akgul O"],"additional_accession":[]},"is_claimable":false,"name":"New CagL Amino Acid Polymorphism Patterns of <i>Helicobacter pylori</i> in Peptic Ulcer and Non-Ulcer Dyspepsia.","description":"<i>Background and Objectives</i>: <i>Helicobacter pylori</i> infection is associated with chronic gastritis, ulcers, and gastric cancer. The <i>H. pylori</i> Type 4 secretion system (T4SS) translocates the CagA protein into host cells and plays an essential role in initiating gastric carcinogenesis. The CagL protein is a component of the T4SS. CagL amino acid polymorphisms are correlated with clinical outcomes. We aimed to study the association between CagL amino acid polymorphisms and peptic ulcer disease (PUD) and non-ulcer dyspepsia (NUD). <i>Materials and Methods</i>: A total of 99 patients (PUD, 46; NUD, 53) were enrolled and screened for <i>H. pylori</i> by qPCR from antrum biopsy samples. The amino acid polymorphisms of CagL were analyzed using DNA sequencing, followed by the MAFFT ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-21T03:10:51.648Z","creation":"2025-02-19T03:24:19.642Z"},"accession":"S-EPMC9782086","cross_references":{"pubmed":["36556940"],"doi":["10.3390/medicina58121738"]}}