{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(24)"],"submitter":["Cassano V"],"pubmed_abstract":["Recent studies suggest a pathogenetic association between metabolic disturbances, including type 2 diabetes (T2DM), and cognitive decline and indicate that T2DM may represent a risk factor for Alzheimer's disease (AD). There are a number of experimental studies presenting evidence that ranolazine, an antianginal drug, acts as a neuroprotective drug. The aim of the present study was to evaluate the effects of ranolazine on hippocampal neurodegeneration and astrocytes activation in a T2DM rat model. Diabetes was induced by a high fat diet (HFD) and streptozotocin (STZ) injection. Animals were divided into the following groups: HFD/STZ + Ranolazine, HFD/STZ + Metformin, HFD/STZ + Vehicle, NCD + Vehicle, NCD + Ranolazine and NCD + Metformin. The presence of neurodegeneration was evaluated in t"],"journal":["International journal of molecular sciences"],"pagination":["16160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782607"],"repository":["biostudies-literature"],"pubmed_title":["Ranolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes."],"pmcid":["PMC9782607"],"pubmed_authors":["Citraro R","Russo E","Tallarico M","Cassano V","De Sarro G","Hribal ML","Leo A","De Sarro C","Iannone M","Armentaro G","Sciacqua A"],"additional_accession":[]},"is_claimable":false,"name":"Ranolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes.","description":"Recent studies suggest a pathogenetic association between metabolic disturbances, including type 2 diabetes (T2DM), and cognitive decline and indicate that T2DM may represent a risk factor for Alzheimer's disease (AD). There are a number of experimental studies presenting evidence that ranolazine, an antianginal drug, acts as a neuroprotective drug. The aim of the present study was to evaluate the effects of ranolazine on hippocampal neurodegeneration and astrocytes activation in a T2DM rat model. Diabetes was induced by a high fat diet (HFD) and streptozotocin (STZ) injection. Animals were divided into the following groups: HFD/STZ + Ranolazine, HFD/STZ + Metformin, HFD/STZ + Vehicle, NCD + Vehicle, NCD + Ranolazine and NCD + Metformin. The presence of neurodegeneration was evaluated in t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:18.874Z","creation":"2024-11-20T04:16:35.454Z"},"accession":"S-EPMC9782607","cross_references":{"pubmed":["36555798"],"doi":["10.3390/ijms232416160"]}}