biostudies-literatureUnknown23(24)Cassano VRecent studies suggest a pathogenetic association between metabolic disturbances, including type 2 diabetes (T2DM), and cognitive decline and indicate that T2DM may represent a risk factor for Alzheimer's disease (AD). There are a number of experimental studies presenting evidence that ranolazine, an antianginal drug, acts as a neuroprotective drug. The aim of the present study was to evaluate the effects of ranolazine on hippocampal neurodegeneration and astrocytes activation in a T2DM rat model. Diabetes was induced by a high fat diet (HFD) and streptozotocin (STZ) injection. Animals were divided into the following groups: HFD/STZ + Ranolazine, HFD/STZ + Metformin, HFD/STZ + Vehicle, NCD + Vehicle, NCD + Ranolazine and NCD + Metformin. The presence of neurodegeneration was evaluated in tInternational journal of molecular sciences16160https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782607biostudies-literatureRanolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes.PMC9782607Citraro RRusso ETallarico MCassano VDe Sarro GHribal MLLeo ADe Sarro CIannone MArmentaro GSciacqua AfalseRanolazine Attenuates Brain Inflammation in a Rat Model of Type 2 Diabetes.Recent studies suggest a pathogenetic association between metabolic disturbances, including type 2 diabetes (T2DM), and cognitive decline and indicate that T2DM may represent a risk factor for Alzheimer's disease (AD). There are a number of experimental studies presenting evidence that ranolazine, an antianginal drug, acts as a neuroprotective drug. The aim of the present study was to evaluate the effects of ranolazine on hippocampal neurodegeneration and astrocytes activation in a T2DM rat model. Diabetes was induced by a high fat diet (HFD) and streptozotocin (STZ) injection. Animals were divided into the following groups: HFD/STZ + Ranolazine, HFD/STZ + Metformin, HFD/STZ + Vehicle, NCD + Vehicle, NCD + Ranolazine and NCD + Metformin. The presence of neurodegeneration was evaluated in t2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:18.874Z2024-11-20T04:16:35.454ZS-EPMC97826073655579810.3390/ijms232416160