{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abdelghafour MM"],"funding":["Hungarian Scientific Research Fund","Joint executive program between the Arab Republic of Egypt and Hungary","Stipendium Hungaricum","Ministry for Innovation and Technology","Hungarian Academy of Sciences"],"pagination":["2723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(12)"],"pubmed_abstract":["A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7-45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10% <i>w</i>/<i>v</i> PVA-CHO/CHIT-SH hydrogel at 1647 cm<sup>-1</sup>, indicating the formation of a Schiff base (-CH=N-) and confirming the interaction between the "],"journal":["Pharmaceutics"],"pubmed_title":["Self-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone."],"pmcid":["PMC9782908"],"funding_grant_id":["OTKA K 132446","Mohamed M. Abdelghafour","OTKA FK 134684","UNKP-22-5 New National Excellence Program","TKP2021-EGA-28","János Bolyai Research Scholarship"],"pubmed_authors":["Szabo D","Rovo L","Szatmari I","Abdelghafour MM","Ambrus R","Keller-Pinter A","Janovak L","Deak A","Kiss T","Budai-Szucs M","Katona G","Lorinczi B"],"additional_accession":[]},"is_claimable":false,"name":"Self-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone.","description":"A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7-45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10% <i>w</i>/<i>v</i> PVA-CHO/CHIT-SH hydrogel at 1647 cm<sup>-1</sup>, indicating the formation of a Schiff base (-CH=N-) and confirming the interaction between the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:11.928Z","creation":"2025-04-04T08:00:11.928Z"},"accession":"S-EPMC9782908","cross_references":{"pubmed":["36559217"],"doi":["10.3390/pharmaceutics14122723"]}}