biostudies-literatureAbdelghafour MMHungarian Scientific Research FundJoint executive program between the Arab Republic of Egypt and HungaryStipendium HungaricumMinistry for Innovation and TechnologyHungarian Academy of Sciences2723https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782908biostudies-literatureUnknown14(12)A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7-45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10% <i>w</i>/<i>v</i> PVA-CHO/CHIT-SH hydrogel at 1647 cm^-1, indicating the formation of a Schiff base (-CH=N-) and confirming the interaction between the PharmaceuticsSelf-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone.PMC9782908OTKA K 132446Mohamed M. AbdelghafourOTKA FK 134684UNKP-22-5 New National Excellence ProgramTKP2021-EGA-28János Bolyai Research ScholarshipSzabo DRovo LSzatmari IAbdelghafour MMAmbrus RKeller-Pinter AJanovak LDeak AKiss TBudai-Szucs MKatona GLorinczi BfalseSelf-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone.A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7-45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10% <i>w</i>/<i>v</i> PVA-CHO/CHIT-SH hydrogel at 1647 cm^-1, indicating the formation of a Schiff base (-CH=N-) and confirming the interaction between the 2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:11.928Z2025-04-04T08:00:11.928ZS-EPMC97829083655921710.3390/pharmaceutics14122723