{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shrestha R"],"funding":["Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) ."],"pagination":["2102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782963"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["This work aims to prepare pure Chlorin e6 (Ce6) and establish Ce6-mediated photodynamic therapy (Ce6-PDT) as a better therapy option for canine tumors as well as mouse tumor models. Five dogs suffering from various cancers were treated with Ce6-PDT from one to several times. After receiving the Ce6 (2.5 mg/kg) for 3 h, tumors were illuminated superficially or interstitially with 660 nm light. Two dogs underwent Ce6-guided fluorescence imaging by photodynamic diagnosis (PDD). Cell proliferation and apoptosis were detected by the 4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot assay, respectively. Ce6-PDT efficacy was also determined using melanoma and pancreatic cancer mouse models. Two veterinary patients with mammary carcinoma and histiocytic sarcom"],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["Effect of Photodynamic Therapy with Chlorin e6 on Canine Tumors."],"pmcid":["PMC9782963"],"funding_grant_id":["(NTIS Number: 1711135018, RS-2020-KD000106)"],"pubmed_authors":["Gurung P","Bae S","Thapa Magar TB","Kim YT","Lee K","Lim J","Kim YW","Lee HJ","Shrestha R"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Photodynamic Therapy with Chlorin e6 on Canine Tumors.","description":"This work aims to prepare pure Chlorin e6 (Ce6) and establish Ce6-mediated photodynamic therapy (Ce6-PDT) as a better therapy option for canine tumors as well as mouse tumor models. Five dogs suffering from various cancers were treated with Ce6-PDT from one to several times. After receiving the Ce6 (2.5 mg/kg) for 3 h, tumors were illuminated superficially or interstitially with 660 nm light. Two dogs underwent Ce6-guided fluorescence imaging by photodynamic diagnosis (PDD). Cell proliferation and apoptosis were detected by the 4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot assay, respectively. Ce6-PDT efficacy was also determined using melanoma and pancreatic cancer mouse models. Two veterinary patients with mammary carcinoma and histiocytic sarcom","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:08.952Z","creation":"2025-04-04T08:00:08.952Z"},"accession":"S-EPMC9782963","cross_references":{"pubmed":["36556469"],"doi":["10.3390/life12122102"]}}