biostudies-literatureUnknown13Zhao J<h4>Background</h4>It is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is inconsistent. The aim of this meta-analysis was to evaluate the association of complement components with the risk and severity of NAFLD.<h4>Methods</h4>We searched PubMed, Embase, Cochrane Library, Google Scholar, Scopus, and ZhiWang Chinese databases from inception to May 2022 for observational studies reporting the risk of NAFLD with complement components. Random-effects meta-analysis was used to obtain pooled estimates of the effect due to heterogeneity.<h4>Results</h4>We identifieFrontiers in immunology1054159https://www.ebi.ac.uk/biostudies/studies/S-EPMC9782972biostudies-literatureAssociation of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis.PMC9782972Liu YFan XGao LHan JZhao JLu PWang ZWu YCheng YWu XShi YfalseAssociation of complement components with the risk and severity of NAFLD: A systematic review and meta-analysis.<h4>Background</h4>It is generally believed that complement system is strongly associated with the risk of nonalcoholic fatty liver disease (NAFLD). However, complement system contains a variety of complement components, and the relationship between complement components and the risk and severity of NAFLD is inconsistent. The aim of this meta-analysis was to evaluate the association of complement components with the risk and severity of NAFLD.<h4>Methods</h4>We searched PubMed, Embase, Cochrane Library, Google Scholar, Scopus, and ZhiWang Chinese databases from inception to May 2022 for observational studies reporting the risk of NAFLD with complement components. Random-effects meta-analysis was used to obtain pooled estimates of the effect due to heterogeneity.<h4>Results</h4>We identifie2022-01-01T00:00:00Z20222025-04-04T21:54:42.894Z2024-11-20T22:40:59.874ZS-EPMC97829723656988210.3389/fimmu.2022.1054159