{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["MacCuaig WM"],"funding":["NIBIB NIH HHS","U.S. Department of Health and Human Services","NCI NIH HHS"],"pagination":["49614-49630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9783196"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(42)"],"pubmed_abstract":["Nanoparticles are widely studied as theranostic vehicles for cancer; however, clinical translation has been limited due to poor tumor specificity. Features that maximize tumor uptake remain controversial, particularly when using clinically relevant models. We report a systematic study that assesses two major features for the impact on tumor specificity, <i>i</i>.<i>e</i>., active vs passive targeting and nanoparticle size, to evaluate relative influences <i>in vivo</i>. Active targeting via the V7 peptide is superior to passive targeting for uptake by pancreatic tumors, irrespective of nanoparticle size, observed through <i>in vivo</i> imaging. Size has a secondary effect on uptake for actively targeted nanoparticles in which 26 nm nanoparticles outperform larger 45 and 73 nm nanoparticles. Nanoparticle size had no significant effect on uptake for passively targeted nanoparticles. Results highlight the superiority of active targeting over nanoparticle size for tumor uptake. These findings suggest a framework for optimizing similar nonaggregate nanoparticles for theranostic treatment of recalcitrant cancers."],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating Tumor-Specific Uptake in Orthotopic Pancreatic Cancer."],"pmcid":["PMC9783196"],"funding_grant_id":["R01 EB020125","R01 CA205941","R01CA212350","R01CA205941","R01 CA212350","P30CA225520","P30 CA225520","R01EB020125"],"pubmed_authors":["McNally MW","Samykutty A","MacCuaig WM","Chuong P","Behkam B","Mukherjee P","Fouts BL","Grizzle WE","McNally LR","Li M","Jasinski JB"],"additional_accession":[]},"is_claimable":false,"name":"Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating Tumor-Specific Uptake in Orthotopic Pancreatic Cancer.","description":"Nanoparticles are widely studied as theranostic vehicles for cancer; however, clinical translation has been limited due to poor tumor specificity. Features that maximize tumor uptake remain controversial, particularly when using clinically relevant models. We report a systematic study that assesses two major features for the impact on tumor specificity, <i>i</i>.<i>e</i>., active vs passive targeting and nanoparticle size, to evaluate relative influences <i>in vivo</i>. Active targeting via the V7 peptide is superior to passive targeting for uptake by pancreatic tumors, irrespective of nanoparticle size, observed through <i>in vivo</i> imaging. Size has a secondary effect on uptake for actively targeted nanoparticles in which 26 nm nanoparticles outperform larger 45 and 73 nm nanoparticles. Nanoparticle size had no significant effect on uptake for passively targeted nanoparticles. Results highlight the superiority of active targeting over nanoparticle size for tumor uptake. These findings suggest a framework for optimizing similar nonaggregate nanoparticles for theranostic treatment of recalcitrant cancers.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T21:55:16.941Z","creation":"2025-04-04T21:55:16.941Z"},"accession":"S-EPMC9783196","cross_references":{"pubmed":["34653338"],"doi":["10.1021/acsami.1c09379"]}}