biostudies-literatureUnknown10(12)Elkhadry SWChildren with chronic medical conditions are more susceptible to developing a serious negative outcome from corona virus disease 2019 (COVID-19) than healthy children. This study investigated the extent of COVID-19 vaccine hesitancy (VH) and its predictors in parents of children with chronic liver disease (CLD) in Egypt.<h4>Methods</h4>A cross-sectional study was conducted at the National Liver Institute from September to October 2022, using a random sampling method. Data were collected using the validated Arabic version of parents' attitudes about childhood vaccines (PACV) scale. Structural equation modeling (SEM) and discriminant analysis were used to identify direct and indirect determinants of VH.<h4>Results</h4>Of the 173 participating parents, 81.5% hesitated to vaccinate their childVaccines2094https://www.ebi.ac.uk/biostudies/studies/S-EPMC9783335biostudies-literatureCOVID-19 Vaccine Hesitancy among Parents of Children with Chronic Liver Diseases.PMC9783335Bahwashy HAAElkhadry SWSalem TAEHGoda SSYoussef NHussein MElshabrawy AGhazy RMfalseCOVID-19 Vaccine Hesitancy among Parents of Children with Chronic Liver Diseases.Children with chronic medical conditions are more susceptible to developing a serious negative outcome from corona virus disease 2019 (COVID-19) than healthy children. This study investigated the extent of COVID-19 vaccine hesitancy (VH) and its predictors in parents of children with chronic liver disease (CLD) in Egypt.<h4>Methods</h4>A cross-sectional study was conducted at the National Liver Institute from September to October 2022, using a random sampling method. Data were collected using the validated Arabic version of parents' attitudes about childhood vaccines (PACV) scale. Structural equation modeling (SEM) and discriminant analysis were used to identify direct and indirect determinants of VH.<h4>Results</h4>Of the 173 participating parents, 81.5% hesitated to vaccinate their child2022-01-01T00:00:00Z2022 Dec2025-04-22T13:25:33.615Z2025-04-06T00:39:20.029ZS-EPMC97833353656050410.3390/vaccines10122094