{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Du X"],"funding":["Natural Science Foundation of Tianjin City","Science & Technology Development Fund of Tianjin Education Commission for Higher Education","Tianjin Key Technology R&D Program","National Natural Science Foundation of China","China Postdoctoral Science Foundation","Tianjin Key Project for Chronic Diseases Prevention","National Key Research and Development Program of China"],"pagination":["156-169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9783440"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(1)"],"pubmed_abstract":["Functional connectivity (FC) disruption is a remarkable characteristic of schizophrenia. However, heterogeneous patterns reported across sites severely hindered its clinical generalization. Based on qualified nodal-based FC of 340 schizophrenia patients (SZ) and 348 normal controls (NC) acquired from seven different scanners, this study compared four commonly used site-effect correction methods in removing the site-related heterogeneities, and then tried to cluster the abnormal FCs into several replicable and independent disrupted subnets across sites, related them to clinical symptoms, and evaluated their potentials in schizophrenia classification. Among the four site-related heterogeneity correction methods, ComBat harmonization (F1 score: 0.806 ± 0.145) achieved the overall best balance"],"journal":["Human brain mapping"],"pubmed_title":["Unraveling schizophrenia replicable functional connectivity disruption patterns across sites."],"pmcid":["PMC9783440"],"funding_grant_id":["17JCYBJC29200","19JCYBJC25100","81601473","81571659","2018YFC1314300","81771818","17ZXMFSY00070","81971599","17ZXMFSY00090","2017YFC0909200","2017M611175","2018KJ082","82030053"],"pubmed_authors":["Ding H","Li J","Xie Y","Du X","Wei X","Chai C","Qin W","Zhuo C","Yu C","Zhang Y","Liang M","Ji Y","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Unraveling schizophrenia replicable functional connectivity disruption patterns across sites.","description":"Functional connectivity (FC) disruption is a remarkable characteristic of schizophrenia. However, heterogeneous patterns reported across sites severely hindered its clinical generalization. Based on qualified nodal-based FC of 340 schizophrenia patients (SZ) and 348 normal controls (NC) acquired from seven different scanners, this study compared four commonly used site-effect correction methods in removing the site-related heterogeneities, and then tried to cluster the abnormal FCs into several replicable and independent disrupted subnets across sites, related them to clinical symptoms, and evaluated their potentials in schizophrenia classification. Among the four site-related heterogeneity correction methods, ComBat harmonization (F1 score: 0.806 ± 0.145) achieved the overall best balance","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T12:09:48.827Z","creation":"2025-04-04T12:09:48.827Z"},"accession":"S-EPMC9783440","cross_references":{"pubmed":["36222054"],"doi":["10.1002/hbm.26108"]}}