biostudies-literatureUnknown27(24)Brol ADeamination of 1-aminoalkylphosphonic acids in the reaction with HNO<sub>2</sub> (generated "in situ" from NaNO<sub>2</sub>) yields a mixture of substitution products (1-hydroxyalkylphosphonic acids), elimination products (vinylphosphonic acid derivatives), rearrangement and substitution products (2-hydroxylkylphosphonic acids) as well as H<sub>3</sub>PO<sub>4</sub>. The variety of formed reaction products suggests that 1-phosphonoalkylium ions may be intermediates in such deamination reactions.Molecules (Basel, Switzerland)8849https://www.ebi.ac.uk/biostudies/studies/S-EPMC9783495biostudies-literatureDeamination of 1-Aminoalkylphosphonic Acids: Reaction Intermediates and Selectivity.PMC9783495Brol AOlszewski TKfalseDeamination of 1-Aminoalkylphosphonic Acids: Reaction Intermediates and Selectivity.Deamination of 1-aminoalkylphosphonic acids in the reaction with HNO<sub>2</sub> (generated "in situ" from NaNO<sub>2</sub>) yields a mixture of substitution products (1-hydroxyalkylphosphonic acids), elimination products (vinylphosphonic acid derivatives), rearrangement and substitution products (2-hydroxylkylphosphonic acids) as well as H<sub>3</sub>PO<sub>4</sub>. The variety of formed reaction products suggests that 1-phosphonoalkylium ions may be intermediates in such deamination reactions.2022-01-01T00:00:00Z2022 Dec2025-04-22T13:16:33.382Z2025-04-06T00:39:05.914ZS-EPMC97834953655797910.3390/molecules27248849