{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dzedulionyte K"],"funding":["Internal Grant Agency of Palacký University","Lietuvos Mokslo Taryba"],"pagination":["8666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9783606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(24)"],"pubmed_abstract":["A general approach towards the synthesis of tetrahydro-4<i>H</i>-pyrazolo[1,5-<i>a</i>][1,4]diazepin-4-one, tetrahydro[1,4]diazepino[1,2-<i>a</i>]indol-1-one and tetrahydro-1<i>H</i>-benzo[4,5]imidazo[1,2-<i>a</i>][1,4]diazepin-1-one derivatives was introduced. A regioselective strategy was developed for synthesizing ethyl 1-(oxiran-2-ylmethyl)-1<i>H</i>-pyrazole-5-carboxylates from easily accessible 3(5)-aryl- or methyl-1<i>H</i>-pyrazole-5(3)-carboxylates. Obtained intermediates were further treated with amines resulting in oxirane ring-opening and direct cyclisation-yielding target pyrazolo[1,5-<i>a</i>][1,4]diazepin-4-ones. A straightforward two-step synthetic approach was applied to expand the current study and successfully functionalize ethyl 1<i>H</i>-indole- and ethyl 1<i>H</i>-ben"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Convenient Synthesis of <i>N</i>-Heterocycle-Fused Tetrahydro-1,4-diazepinones."],"pmcid":["PMC9783606"],"funding_grant_id":["No. S-MIP-20-60","IGA_PrF_2022_012"],"pubmed_authors":["Dzedulionyte K","Moravek V","Veiksaite M","Rackauskiene G","Sackus A","Arbaciauskiene E","Malinauskiene V","Zukauskaite A"],"additional_accession":[]},"is_claimable":false,"name":"Convenient Synthesis of <i>N</i>-Heterocycle-Fused Tetrahydro-1,4-diazepinones.","description":"A general approach towards the synthesis of tetrahydro-4<i>H</i>-pyrazolo[1,5-<i>a</i>][1,4]diazepin-4-one, tetrahydro[1,4]diazepino[1,2-<i>a</i>]indol-1-one and tetrahydro-1<i>H</i>-benzo[4,5]imidazo[1,2-<i>a</i>][1,4]diazepin-1-one derivatives was introduced. A regioselective strategy was developed for synthesizing ethyl 1-(oxiran-2-ylmethyl)-1<i>H</i>-pyrazole-5-carboxylates from easily accessible 3(5)-aryl- or methyl-1<i>H</i>-pyrazole-5(3)-carboxylates. Obtained intermediates were further treated with amines resulting in oxirane ring-opening and direct cyclisation-yielding target pyrazolo[1,5-<i>a</i>][1,4]diazepin-4-ones. A straightforward two-step synthetic approach was applied to expand the current study and successfully functionalize ethyl 1<i>H</i>-indole- and ethyl 1<i>H</i>-ben","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T15:42:34.947Z","creation":"2025-04-05T15:42:34.947Z"},"accession":"S-EPMC9783606","cross_references":{"pubmed":["36557800"],"doi":["10.3390/molecules27248666"]}}