biostudies-literatureYang MChengdu Science and Technology BureauNational Natural Science Foundation of ChinaSpecial Scientific Research Fund of the First Affiliated Hospital of Chengdu Medical UniversityKey project of Chengdu Medical University-Chengdu Seventh People's Hospital Joint Scientific Research FundScience &amp; Technology Department of Sichuan ProvinceSichuan Science and Technology Program461https://www.ebi.ac.uk/biostudies/studies/S-EPMC9784080biostudies-literatureUnknown9(12)<h4>Background</h4>Excessive supraventricular ectopic activity (ESVEA) is correlated with the development of atrial fibrillation (AF) and is frequently observed in ischemic stroke patients. This meta-analysis aims to summarize the evidence on the association between ESVEA and the risk of AF and stroke.<h4>Methods</h4>PubMed and Embase databases were systematically searched to identify all publications providing relevant data from inception to 23 August 2022. Hazard ratio (HR) and 95% confidence interval (CI) were pooled using fixed-effect or random-effect models.<h4>Results</h4>We included 23,272 participants from 20 studies. Pooled results showed that ESVEA was associated with an increased risk of AF in the general population (HR: 2.57; 95% CI 2.16-3.05), increased risk of AF in ischemic Journal of cardiovascular development and diseaseExcessive Supraventricular Ectopic Activity and the Risk of Atrial Fibrillation and Stroke: A Systematic Review and Meta-Analysis.PMC97840802020-GH02-00057-HZ2021YFS0376CYFY2021YB042021LHJYZD-0182171295Yang JLi ZZhu LYang MTan SLin YWang XCheng HZheng DfalseExcessive Supraventricular Ectopic Activity and the Risk of Atrial Fibrillation and Stroke: A Systematic Review and Meta-Analysis.<h4>Background</h4>Excessive supraventricular ectopic activity (ESVEA) is correlated with the development of atrial fibrillation (AF) and is frequently observed in ischemic stroke patients. This meta-analysis aims to summarize the evidence on the association between ESVEA and the risk of AF and stroke.<h4>Methods</h4>PubMed and Embase databases were systematically searched to identify all publications providing relevant data from inception to 23 August 2022. Hazard ratio (HR) and 95% confidence interval (CI) were pooled using fixed-effect or random-effect models.<h4>Results</h4>We included 23,272 participants from 20 studies. Pooled results showed that ESVEA was associated with an increased risk of AF in the general population (HR: 2.57; 95% CI 2.16-3.05), increased risk of AF in ischemic 2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:09.333Z2025-04-04T08:00:09.333ZS-EPMC97840803654745910.3390/jcdd9120461