biostudies-literatureLu QScience-Technology Program of GuangxiBose Talent HighlandNatural Science Foundation of YMUNGuangxi Training Program for Medical High-level Academic Leadersthe Science-Technology Program of GuangxiNational Natural Science Foundation of ChinaBaise Science and Technology Plan Project1430https://www.ebi.ac.uk/biostudies/studies/S-EPMC9784484biostudies-literatureUnknown11(12)<h4>Background</h4><i>L. monocytogenes</i> and <i>L. ivanovii</i>, the only two pathogens of <i>Listeria</i>, can survive in various environments, having different pathogenic characteristics. However, the genetic basis of their excellent adaptability and differences in pathogenicity has still not been completely elucidated.<h4>Methods</h4>We performed a comparative genomic analysis based on 275 <i>L. monocytogenes</i>, 10 <i>L. ivanovii,</i> and 22 non-pathogenic <i>Listeria</i> strains.<h4>Results</h4>Core/pan-genome analysis revealed that 975 gene families were conserved in all the studied strains. Additionally, 204, 242, and 756 gene families existed uniquely in <i>L. monocytogenes</i>, <i>L. ivanovii,</i> and both, respectively. Functional annotation partially verified that these uniquPathogens (Basel, Switzerland)Comparative Genomics Reveal the Utilization Ability of Variable Carbohydrates as Key Genetic Features of <i>Listeria</i> Pathogens in Their Pathogenic Lifestyles.PMC9784484Nos. AD19245174AD19245174Nos. 81860489yy2020ky0212020-3-2baike202236baike202236, baike202235baike2022356 of Guiweikejiaofa (2020)-1581860489Yi XLong XCao DZhu XYang ALong QLu QfalseComparative Genomics Reveal the Utilization Ability of Variable Carbohydrates as Key Genetic Features of <i>Listeria</i> Pathogens in Their Pathogenic Lifestyles.<h4>Background</h4><i>L. monocytogenes</i> and <i>L. ivanovii</i>, the only two pathogens of <i>Listeria</i>, can survive in various environments, having different pathogenic characteristics. However, the genetic basis of their excellent adaptability and differences in pathogenicity has still not been completely elucidated.<h4>Methods</h4>We performed a comparative genomic analysis based on 275 <i>L. monocytogenes</i>, 10 <i>L. ivanovii,</i> and 22 non-pathogenic <i>Listeria</i> strains.<h4>Results</h4>Core/pan-genome analysis revealed that 975 gene families were conserved in all the studied strains. Additionally, 204, 242, and 756 gene families existed uniquely in <i>L. monocytogenes</i>, <i>L. ivanovii,</i> and both, respectively. Functional annotation partially verified that these uniqu2022-01-01T00:00:00Z2022 Nov2026-06-20T03:18:56.794Z2025-04-05T14:57:40.264ZS-EPMC97844843655876510.3390/pathogens11121430