{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Addo PW"],"funding":["Natural Sciences and Engineering Research Council Collaborative Research and Development","Collaborative Research and Training Experience-Quality Assurance and Quality Control for Cannabis Production"],"pagination":["8803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9784742"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(24)"],"pubmed_abstract":["Limited studies have explored different extraction techniques that improve cannabis extraction with scale-up potential. Ultrasound-assisted and microwave-assisted extraction were evaluated to maximize the yield and concentration of cannabinoids and terpenes. A central composite rotatable design was used to optimize independent factors (sample-to-solvent ratio, extraction time, extraction temperature, and duty cycle). The optimal conditions for ultrasound- and microwave-assisted extraction were the sample-to-solvent ratios of 1:15 and 1:14.4, respectively, for 30 min at 60 °C. Ultrasound-assisted extraction yielded 14.4% and 14.2% more oil and terpenes, respectively, compared with microwave-assisted extracts. Ultrasound-assisted extraction increased cannabinoid concentration from 13.2-39.2%"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Microwave- and Ultrasound-Assisted Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology."],"pmcid":["PMC9784742"],"funding_grant_id":["NSERC CRDPJ 543704-19","CREATE CREAT/543319- 2020"],"pubmed_authors":["Raghavan V","MacPherson S","Addo PW","Lefsrud M","McRae G","Bilodeau SE","Paris M","Sagili SUKR","Gladu-Gallant FA","Bates J","Orsat V","MacKenzie DA"],"additional_accession":[]},"is_claimable":false,"name":"Microwave- and Ultrasound-Assisted Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology.","description":"Limited studies have explored different extraction techniques that improve cannabis extraction with scale-up potential. Ultrasound-assisted and microwave-assisted extraction were evaluated to maximize the yield and concentration of cannabinoids and terpenes. A central composite rotatable design was used to optimize independent factors (sample-to-solvent ratio, extraction time, extraction temperature, and duty cycle). The optimal conditions for ultrasound- and microwave-assisted extraction were the sample-to-solvent ratios of 1:15 and 1:14.4, respectively, for 30 min at 60 °C. Ultrasound-assisted extraction yielded 14.4% and 14.2% more oil and terpenes, respectively, compared with microwave-assisted extracts. Ultrasound-assisted extraction increased cannabinoid concentration from 13.2-39.2%","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:16.442Z","creation":"2025-04-04T08:00:16.442Z"},"accession":"S-EPMC9784742","cross_references":{"pubmed":["36557949"],"doi":["10.3390/molecules27248803"]}}