biostudies-literatureBao JNational Natural Science Foundation of China1238https://www.ebi.ac.uk/biostudies/studies/S-EPMC9785059biostudies-literatureUnknown8(12)(1) Background: Pyricularia oryzae, the causal agent of rice blast disease, is one of the major rice pathogens. The complex population structure of P. oryzae facilitates the rapid virulence variations, which make the blast disease a serious challenge for global food security. There is a large body of existing genomics research on P. oryzae, however the population structure at the pan-genome level is not clear, and the mechanism of genetic divergence and virulence variations of different sub-populations is also unknown. (2) Methods: Based on the genome data published in the NCBI, we constructed a pan-genome database of P. oryzae, which consisted of 156 strains (117 isolated from rice and 39 isolated from other hosts). (3) Results: The pan-genome contained a totalJournal of fungi (Basel, Switzerland)Pan-Genomics Reveals a New Variation Pattern of Secreted Proteins in Pyricularia oryzae.PMC9785059U1805232320019763227007832172365Zheng HBao JChen MXie JChen XChen STang WWang ZfalsePan-Genomics Reveals a New Variation Pattern of Secreted Proteins in Pyricularia oryzae.(1) Background: Pyricularia oryzae, the causal agent of rice blast disease, is one of the major rice pathogens. The complex population structure of P. oryzae facilitates the rapid virulence variations, which make the blast disease a serious challenge for global food security. There is a large body of existing genomics research on P. oryzae, however the population structure at the pan-genome level is not clear, and the mechanism of genetic divergence and virulence variations of different sub-populations is also unknown. (2) Methods: Based on the genome data published in the NCBI, we constructed a pan-genome database of P. oryzae, which consisted of 156 strains (117 isolated from rice and 39 isolated from other hosts). (3) Results: The pan-genome contained a total2022-01-01T00:00:00Z2022 Nov2026-04-08T11:04:33.29Z2024-11-09T20:33:43.44ZS-EPMC97850593654757110.3390/jof8121238