{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Affeldt P"],"funding":["Ministry of Science North Rhine-Westphalia and the German Research Foundation"],"pagination":["2646"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9785871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(12)"],"pubmed_abstract":["Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed. In the present study, the immune response to either a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients. SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.1 were quantified. After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate agai"],"journal":["Viruses"],"pubmed_title":["Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients."],"pmcid":["PMC9785871"],"funding_grant_id":["DFG, DI 1501/9-2, MU 3629/6-1"],"pubmed_authors":["Muller RU","Oehm S","Gies M","Affeldt P","Heger E","Platen E","Brensing KA","Hinrichs S","Stippel D","Klein F","Kurschat C","Wirtz M","Benzing T","Koehler FC","Butt L","Di Cristanziano V","Grundmann F","Adam V","Kalisch N","Steger G"],"additional_accession":[]},"is_claimable":false,"name":"Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients.","description":"Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed. In the present study, the immune response to either a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients. SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.1 were quantified. After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate agai","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T15:59:52.741Z","creation":"2025-04-07T02:57:08.903Z"},"accession":"S-EPMC9785871","cross_references":{"pubmed":["36560648"],"doi":["10.3390/v14122646"]}}