{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ding C"],"funding":["Development Project of Hunan Development and Reform Commission","Natural Science Foundation of Hunan Province","The Science and Technology Innovation Program of Hunan Province","Scientific Research Project of Hunan Provincial Health Commission","National Natural Science Foundation of China","New Technology Incubation Funds in Ophthalmology"],"pagination":["2751"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9786316"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(12)"],"pubmed_abstract":["Diabetic retinopathy (DR) is a major cause of blindness worldwide and may be non-proliferative (NPDR) or proliferative (PDR). To Investig.gate the metabolomic and lipidomic characteristics of plasma in DR patients, plasma samples were collected from patients with type 2 diabetes mellitus (DR group) with PDR (<i>n</i> = 27), NPDR (<i>n</i> = 18), or no retinopathy (controls, <i>n</i> = 21). Levels of 54 and 41 metabolites were significantly altered in the plasma of DR patients under positive and negative ion modes, respectively. By subgroup analysis, 74 and 29 significantly changed plasma metabolites were detected in PDR patients compared with NPDR patients under positive and negative ion modes, respectively. KEGG analysis indicated that pathways such as biosynthesis of amino acids and neur"],"journal":["Pharmaceutics"],"pubmed_title":["Integrated Analysis of Metabolomics and Lipidomics in Plasma of T2DM Patients with Diabetic Retinopathy."],"pmcid":["PMC9786316"],"funding_grant_id":["2022JJ30869","2021JJ40885","D202307028349","82271110","2021SK53526","2021-212","202207022574"],"pubmed_authors":["Wang N","Yang Y","Ding C","Yoshida S","Zeng J","Li B","Yue W","Zhou Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Analysis of Metabolomics and Lipidomics in Plasma of T2DM Patients with Diabetic Retinopathy.","description":"Diabetic retinopathy (DR) is a major cause of blindness worldwide and may be non-proliferative (NPDR) or proliferative (PDR). To Investig.gate the metabolomic and lipidomic characteristics of plasma in DR patients, plasma samples were collected from patients with type 2 diabetes mellitus (DR group) with PDR (<i>n</i> = 27), NPDR (<i>n</i> = 18), or no retinopathy (controls, <i>n</i> = 21). Levels of 54 and 41 metabolites were significantly altered in the plasma of DR patients under positive and negative ion modes, respectively. By subgroup analysis, 74 and 29 significantly changed plasma metabolites were detected in PDR patients compared with NPDR patients under positive and negative ion modes, respectively. KEGG analysis indicated that pathways such as biosynthesis of amino acids and neur","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T21:54:56.347Z","creation":"2025-04-04T21:54:56.347Z"},"accession":"S-EPMC9786316","cross_references":{"pubmed":["36559245"],"doi":["10.3390/pharmaceutics14122751"]}}