biostudies-literaturede Souza AMSão Paulo Research FoundationGE Healthcare2715https://www.ebi.ac.uk/biostudies/studies/S-EPMC9786563biostudies-literatureUnknown14(12)<h4>Background</h4>Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [¹¹C](<i>R</i>)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model.<h4>Methods</h4>Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [¹¹C](<i>R</i>)-PK11195 and [¹⁸F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation.<h4>Results</h4>The [¹¹C](<i>R</i>)-PK11195 tumor uptake increased from 3 days to 1 week, and decreased at 2 weeks after cell inoculation, as opposed to the [¹⁸F]FDG uptake, wPharmaceuticsPotential of [¹¹C](<i>R</i>)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model.PMC9786563104.44112496139131 and 104.4411249613913119/15654-2de Paula Faria DReal CCSapienza MTde Souza AMEstessi de Souza LNavarro Marques FLJunqueira MSBuchpiguel CAChammas RfalsePotential of [¹¹C](<i>R</i>)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model.<h4>Background</h4>Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [¹¹C](<i>R</i>)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model.<h4>Methods</h4>Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [¹¹C](<i>R</i>)-PK11195 and [¹⁸F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation.<h4>Results</h4>The [¹¹C](<i>R</i>)-PK11195 tumor uptake increased from 3 days to 1 week, and decreased at 2 weeks after cell inoculation, as opposed to the [¹⁸F]FDG uptake, w2022-01-01T00:00:00Z2022 Dec2025-08-28T03:07:17.442Z2025-04-07T02:58:17.972ZS-EPMC97865633655920910.3390/pharmaceutics14122715