{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ali N"],"funding":["Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU)"],"pagination":["8915"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9786741"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(24)"],"pubmed_abstract":["This research work focuses on the potential application of an organic compound, santalol, obtained from santalum album, in the inhibition of the enzyme tyrosinase, which is actively involved in the biosynthesis of melanin pigment. Over-production of melanin causes undesirable pigmentation in humans as well as other organisms and significantly downgrades their aesthetic value. The study is designed to explain the purification of tyrosinase from the mushroom <i>Agaricus bisporus</i>, followed by activity assays and enzyme kinetics to give insight into the santalol-modulated tyrosinase inhibition in a dose-dependent manner. The multi-spectroscopic techniques such as UV-vis, fluorescence, and isothermal calorimetry are employed to deduce the efficiency of santalol as a potential candidate agai"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches."],"pmcid":["PMC9786741"],"funding_grant_id":["RP-21-09-86"],"pubmed_authors":["Israil","Ali N","Alsalamah SA","Islam A","Beg MA","Parray ZA","Hassan MI","Rudayni HA","Imam MA","Chaudhary AA","Gaur NA","Shamsi A","Alghonaim MI","Zehra Z"],"additional_accession":[]},"is_claimable":false,"name":"Elucidating the Role of Santalol as a Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches.","description":"This research work focuses on the potential application of an organic compound, santalol, obtained from santalum album, in the inhibition of the enzyme tyrosinase, which is actively involved in the biosynthesis of melanin pigment. Over-production of melanin causes undesirable pigmentation in humans as well as other organisms and significantly downgrades their aesthetic value. The study is designed to explain the purification of tyrosinase from the mushroom <i>Agaricus bisporus</i>, followed by activity assays and enzyme kinetics to give insight into the santalol-modulated tyrosinase inhibition in a dose-dependent manner. The multi-spectroscopic techniques such as UV-vis, fluorescence, and isothermal calorimetry are employed to deduce the efficiency of santalol as a potential candidate agai","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-08T03:16:15.576Z","creation":"2025-02-19T03:01:25.676Z"},"accession":"S-EPMC9786741","cross_references":{"pubmed":["36558055"],"doi":["10.3390/molecules27248915"]}}