biostudies-literatureGusmao SBSCoordenação de Aperfeicoamento de Pessoal de Nível SuperiorNational Council for Scientific and Technological Development306https://www.ebi.ac.uk/biostudies/studies/S-EPMC9786793biostudies-literatureUnknown13(4)Strategies for the production of new nanocomposites that promote bone tissue regeneration are important, particularly those that enhance the osteoinduction of hydroxyapatite in situ. Here, we studied and report the synthesis of nanohydroxyapatite and titanate nanotube (nHAp/TiNT) composites formulated at different concentrations (1, 2, 3, and 10 wt % TiNT) by means of a wet aqueous chemical reaction. The addition of TiNT affects the morphology of the nanocomposites, decreasing the average crystallite size from 54 nm (nHAp) to 34 nm (nHAp/TiNT10%), while confirming its interaction with the nanocomposite. The crystallinity index (CI) calculated by Raman spectroscopy and XRD showed that the values decreased according to the increase in TiNT concentration, which confirmed their addition to theJournal of functional biomaterialsNanohydroxyapatite/Titanate Nanotube Composites for Bone Tissue Regeneration.PMC9786793183995400998/2022-0427084/2018-0307901/2019-0Ghosh Ade Menezes ASLobo AOPereira AFMLopes MTPDittz DViana BCPinto LSSMaia Filho ALMAbreu GJPSouza MKGusmao GOMWebster TJGusmao SBSfalseNanohydroxyapatite/Titanate Nanotube Composites for Bone Tissue Regeneration.Strategies for the production of new nanocomposites that promote bone tissue regeneration are important, particularly those that enhance the osteoinduction of hydroxyapatite in situ. Here, we studied and report the synthesis of nanohydroxyapatite and titanate nanotube (nHAp/TiNT) composites formulated at different concentrations (1, 2, 3, and 10 wt % TiNT) by means of a wet aqueous chemical reaction. The addition of TiNT affects the morphology of the nanocomposites, decreasing the average crystallite size from 54 nm (nHAp) to 34 nm (nHAp/TiNT10%), while confirming its interaction with the nanocomposite. The crystallinity index (CI) calculated by Raman spectroscopy and XRD showed that the values decreased according to the increase in TiNT concentration, which confirmed their addition to the2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:03.417Z2025-04-04T08:00:03.417ZS-EPMC97867933654756610.3390/jfb13040306