biostudies-literatureHien HTMThe Ministry of Defence of the Socialist Republic of VietnamVietnam Academy of Science and TechnologyJoint Vietnam–Russia Tropical Science and Technology Research Center780https://www.ebi.ac.uk/biostudies/studies/S-EPMC9787583biostudies-literatureUnknown20(12)<i>Aurantiochytrium</i> is a heterotrophic marine microalga that has potential industrial applications. The main objectives of this study were to isolate an <i>Aurantiochytrium</i> strain from Sand Cay (Son Ca) Island, Vietnam, optimize its culture conditions, determine its nutritional composition, extract polyunsaturated fatty acids (PUFAs) in the free (FFA) and the alkyl ester (FAAE) forms, and evaluate the antioxidation and neuroprotection properties of the PUFAs. <i>Aurantiochytrium</i> sp. SC145 can be grown stably under laboratory conditions. Its culture conditions were optimized for a dry cell weight (DCW) of 31.18 g/L, with total lipids comprising 25.29%, proteins 7.93%, carbohydrates 15.21%, and carotenoid at 143.67 µg/L of DCW. The FAAEs and FFAs extracted from <i>AurantiochytriuMarine drugsCharacterization and Optimization of Culture Conditions for <i>Aurantiochytrium</i> sp. SC145 Isolated from Sand Cay (Son Ca) Island, Vietnam, and Antioxidative and Neuroprotective Activities of Its Polyunsaturated Fatty Acid Mixture.PMC9787583KCB-TS-07VAST04.10/22-23Thu NTHHien HTMLoan VTNguyen TVThom LTDan NTTam LTHong DDHa NCfalseCharacterization and Optimization of Culture Conditions for <i>Aurantiochytrium</i> sp. SC145 Isolated from Sand Cay (Son Ca) Island, Vietnam, and Antioxidative and Neuroprotective Activities of Its Polyunsaturated Fatty Acid Mixture.<i>Aurantiochytrium</i> is a heterotrophic marine microalga that has potential industrial applications. The main objectives of this study were to isolate an <i>Aurantiochytrium</i> strain from Sand Cay (Son Ca) Island, Vietnam, optimize its culture conditions, determine its nutritional composition, extract polyunsaturated fatty acids (PUFAs) in the free (FFA) and the alkyl ester (FAAE) forms, and evaluate the antioxidation and neuroprotection properties of the PUFAs. <i>Aurantiochytrium</i> sp. SC145 can be grown stably under laboratory conditions. Its culture conditions were optimized for a dry cell weight (DCW) of 31.18 g/L, with total lipids comprising 25.29%, proteins 7.93%, carbohydrates 15.21%, and carotenoid at 143.67 µg/L of DCW. The FAAEs and FFAs extracted from <i>Aurantiochytriu2022-01-01T00:00:00Z2022 Dec2025-04-03T22:35:21.768Z2024-10-16T04:05:00.163ZS-EPMC97875833654792710.3390/md20120780