biostudies-literatureUnknown28(8)Pentenero M<h4>Background</h4>Chronic trauma of oral mucosa, resulting from repeated and persistent mechanical irritative action of an intraoral injury agent, has repeatedly been reported to be possibly implicated in the development of oral squamous cell carcinoma (OSCC).<h4>Objectives</h4>The present systematic review aimed to assess whether chronic mechanical trauma can be considered a risk factor for OSCC.<h4>Data sources</h4>PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), Scopus; EMBASE, Web of Science.<h4>Study eligibility criteria</h4>Cohort studies comparing OSCC incidence among subjects with/without chronic mechanical trauma or case-control or cross-sectional studies comparing chronic mechanical trauma among subjects with/without OSCC.<h4>Results</h4>Only one prospective casOral diseases2110-2118https://www.ebi.ac.uk/biostudies/studies/S-EPMC9787889biostudies-literatureChronic mechanical trauma/irritation and oral carcinoma: A systematic review showing low evidence to support an association.PMC9787889Varoni ELodi GManfredi MPentenero MAzzi LfalseChronic mechanical trauma/irritation and oral carcinoma: A systematic review showing low evidence to support an association.<h4>Background</h4>Chronic trauma of oral mucosa, resulting from repeated and persistent mechanical irritative action of an intraoral injury agent, has repeatedly been reported to be possibly implicated in the development of oral squamous cell carcinoma (OSCC).<h4>Objectives</h4>The present systematic review aimed to assess whether chronic mechanical trauma can be considered a risk factor for OSCC.<h4>Data sources</h4>PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), Scopus; EMBASE, Web of Science.<h4>Study eligibility criteria</h4>Cohort studies comparing OSCC incidence among subjects with/without chronic mechanical trauma or case-control or cross-sectional studies comparing chronic mechanical trauma among subjects with/without OSCC.<h4>Results</h4>Only one prospective cas2022-01-01T00:00:00Z2022 Nov2025-04-05T08:47:42.468Z2025-04-05T08:47:42.468ZS-EPMC97878893463758910.1111/odi.14049