{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choroszy M"],"funding":["National Science Centre","Ministry of Education and Science","Ministry of Education and Science in the "Regional Initiative of Excellence" " program for the years 2019-2022, project number 016/RID/2018/19"],"pagination":["1165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9788186"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["In recent years, the importance of the gut microbiome in human health and disease has increased. Growing evidence suggests that gut dysbiosis might be a crucial risk factor for coronary artery disease (CAD). Therefore, we conducted a systematic review and meta-analysis to determine whether or not CAD is associated with specific changes in the gut microbiome. The V3-V4 regions of the 16S rDNA from fecal samples were analyzed to compare the gut microbiome composition between CAD patients and controls. Our search yielded 1181 articles, of which 21 met inclusion criteria for systematic review and 7 for meta-analysis. The alpha-diversity, including observed OTUs, Shannon and Simpson indices, was significantly decreased in CAD, indicating the reduced richness of the gut microbiome. The most cons"],"journal":["Metabolites"],"pubmed_title":["Human Gut Microbiota in Coronary Artery Disease: A Systematic Review and Meta-Analysis."],"pmcid":["PMC9788186"],"funding_grant_id":["RID Z501.20.009","2017/25/N/NZ5/02765","016/RID/2018/19"],"pubmed_authors":["Sawicka-Smiarowska E","Bednarz R","Niemira M","Roleder T","Lerman A","Litwinowicz K","Toya T","Kaminski K","Sobieszczanska B","Choroszy M"],"additional_accession":[]},"is_claimable":false,"name":"Human Gut Microbiota in Coronary Artery Disease: A Systematic Review and Meta-Analysis.","description":"In recent years, the importance of the gut microbiome in human health and disease has increased. Growing evidence suggests that gut dysbiosis might be a crucial risk factor for coronary artery disease (CAD). Therefore, we conducted a systematic review and meta-analysis to determine whether or not CAD is associated with specific changes in the gut microbiome. The V3-V4 regions of the 16S rDNA from fecal samples were analyzed to compare the gut microbiome composition between CAD patients and controls. Our search yielded 1181 articles, of which 21 met inclusion criteria for systematic review and 7 for meta-analysis. The alpha-diversity, including observed OTUs, Shannon and Simpson indices, was significantly decreased in CAD, indicating the reduced richness of the gut microbiome. The most cons","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-04-29T03:22:25.989Z","creation":"2025-04-04T21:54:56.831Z"},"accession":"S-EPMC9788186","cross_references":{"pubmed":["36557203"],"doi":["10.3390/metabo12121165"]}}