{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee JH"],"funding":["Marine Biodiversity Institute of Korea"],"pagination":["776"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9788543"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(12)"],"pubmed_abstract":["Lectin is a carbohydrate-binding protein that recognizes specific cells by binding to cell-surface polysaccharides. Tumor cells generally show various glycosylation patterns, making them distinguishable from non-cancerous cells. Consequently, lectin has been suggested as a good anticancer agent. Herein, the anticancer activity of <i>Bryopsis plumosa</i> lectins (BPL1, BPL2, and BPL3) was screened and tested against lung cancer cell lines (A549, H460, and H1299). BPL2 showed high anticancer activity compared to BPL1 and BPL3. Cell viability was dependent on BPL2 concentration and incubation time. The IC<sub>50</sub> value for lung cancer cells was 50 μg/mL after 24 h of incubation in BPL2 containing medium; however, BPL2 (50 μg/mL) showed weak toxicity in non-cancerous cells (MRC5). BPL2 af"],"journal":["Marine drugs"],"pubmed_title":["Anticancer Activity of Mannose-Specific Lectin, BPL2, from Marine Green Alga <i>Bryopsis plumosa</i>."],"pmcid":["PMC9788543"],"funding_grant_id":["2022M00400"],"pubmed_authors":["Kim H","An HS","Lee SB","Yoon M","Shin JM","Han JW","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Anticancer Activity of Mannose-Specific Lectin, BPL2, from Marine Green Alga <i>Bryopsis plumosa</i>.","description":"Lectin is a carbohydrate-binding protein that recognizes specific cells by binding to cell-surface polysaccharides. Tumor cells generally show various glycosylation patterns, making them distinguishable from non-cancerous cells. Consequently, lectin has been suggested as a good anticancer agent. Herein, the anticancer activity of <i>Bryopsis plumosa</i> lectins (BPL1, BPL2, and BPL3) was screened and tested against lung cancer cell lines (A549, H460, and H1299). BPL2 showed high anticancer activity compared to BPL1 and BPL3. Cell viability was dependent on BPL2 concentration and incubation time. The IC<sub>50</sub> value for lung cancer cells was 50 μg/mL after 24 h of incubation in BPL2 containing medium; however, BPL2 (50 μg/mL) showed weak toxicity in non-cancerous cells (MRC5). BPL2 af","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-04-08T06:28:45.944Z","creation":"2025-04-06T00:38:57.161Z"},"accession":"S-EPMC9788543","cross_references":{"pubmed":["36547923"],"doi":["10.3390/md20120776"]}}