biostudies-literatureUnknown50(6)Chavda NDBiotechnology and Biological Sciences Research CouncilBasement membranes (BMs) are structured regions of the extracellular matrix that provide multiple functions including physical support and acting as a barrier, as a repository for nutrients and growth factors, and as biophysical signalling hubs. At the core of all BMs is the laminin (LM) family of proteins. These large heterotrimeric glycoproteins are essential for tissue integrity, and differences between LM family members represent a key nexus in dictating context and tissue-specific functions. These variations reflect genetic diversity within the family, which allows for multiple structurally and functionally distinct heterotrimers to be produced, each with different architectures and affinities for other matrix proteins and cell surface receptors. The ratios of these LM isoforms also iBiochemical Society transactions1541-1553https://www.ebi.ac.uk/biostudies/studies/S-EPMC9788559biostudies-literatureLaminin N-terminus (LaNt) proteins, laminins and basement membrane regulation.PMC9788559Hamill KJAsiri FMChavda NDSari BfalseLaminin N-terminus (LaNt) proteins, laminins and basement membrane regulation.Basement membranes (BMs) are structured regions of the extracellular matrix that provide multiple functions including physical support and acting as a barrier, as a repository for nutrients and growth factors, and as biophysical signalling hubs. At the core of all BMs is the laminin (LM) family of proteins. These large heterotrimeric glycoproteins are essential for tissue integrity, and differences between LM family members represent a key nexus in dictating context and tissue-specific functions. These variations reflect genetic diversity within the family, which allows for multiple structurally and functionally distinct heterotrimers to be produced, each with different architectures and affinities for other matrix proteins and cell surface receptors. The ratios of these LM isoforms also i2022-01-01T00:00:00Z2022 Dec2025-04-05T11:24:17.554Z2025-04-05T11:24:17.554ZS-EPMC97885593635536710.1042/BST20210240