biostudies-literatureFote GNIA NIH HHSNCRR NIH HHS1161-1171https://www.ebi.ac.uk/biostudies/studies/S-EPMC9788856biostudies-literatureUnknown83(3)<h4>Background</h4>Altered plasma levels of sphingolipids, including sphingomyelins (SM), have been found in mouse models of Alzheimer's disease (AD) and in AD patient plasma samples.<h4>Objective</h4>This study assesses fourteen plasma SM species in a late-onset AD (LOAD) patient cohort (n = 138).<h4>Methods</h4>Specimens from control, preclinical, and symptomatic subjects were analyzed using targeted mass-spectrometry-based metabolomic methods.<h4>Results</h4>Total plasma SM levels were not significantly affected by age or cognitive status. However, one metabolite that has been elevated in manifest AD in several recent studies, SM OHC14:1, was reduced significantly in pre-clinical AD and MCI relative to normal controls.<h4>Conclusion</h4>We recommend additional comprehensive plasma lipidJournal of Alzheimer's disease : JADPlasma Sphingomyelins in Late-Onset Alzheimer's Disease.PMC9788856F30 AG060704R01 AG030753M01 RR000865K08 AG022228P50 AG005142UL1 RR033176U19 AG032438P50 AG016570Wu JMapstone MMacciardi FFote GFederoff HJFiandaca MSfalsePlasma Sphingomyelins in Late-Onset Alzheimer's Disease.<h4>Background</h4>Altered plasma levels of sphingolipids, including sphingomyelins (SM), have been found in mouse models of Alzheimer's disease (AD) and in AD patient plasma samples.<h4>Objective</h4>This study assesses fourteen plasma SM species in a late-onset AD (LOAD) patient cohort (n = 138).<h4>Methods</h4>Specimens from control, preclinical, and symptomatic subjects were analyzed using targeted mass-spectrometry-based metabolomic methods.<h4>Results</h4>Total plasma SM levels were not significantly affected by age or cognitive status. However, one metabolite that has been elevated in manifest AD in several recent studies, SM OHC14:1, was reduced significantly in pre-clinical AD and MCI relative to normal controls.<h4>Conclusion</h4>We recommend additional comprehensive plasma lipid2021-01-01T00:00:00Z20212025-04-18T17:15:05.444Z2025-04-07T04:48:38.44ZS-EPMC97888563439740810.3233/jad-20087110.3233/JAD-200871