{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Kim ED"],"funding":["MEXT | Japan Society for the Promotion of Science","MEXT | Japan Society for the Promotion of Science (JSPS)","Howard Hughes Medical Institute","YLC Program, Nagoya University","Howard Hughes Medical Institute (HHMI)"],"pubmed_abstract":["Chromatin architecture and transcription factor (TF) binding underpin cell-fate specification during development, but their mutual regulatory relationships remain unclear. Here we report an atlas of dynamic chromatin landscapes during stomatal cell-lineage progression, in which sequential cell-state transitions are governed by lineage-specific bHLH TFs. Major reprogramming of chromatin accessibility occurs at the proliferation-to-differentiation transition. We discover novel co-cis regulatory elements (CREs) signifying the early precursor stage, BBR/BPC (GAGA) and bHLH (E-box) motifs, where master-regulatory bHLH TFs, SPEECHLESS and MUTE, consecutively bind to initiate and terminate the proliferative state, respectively. BPC TFs complex with MUTE to repress SPEECHLESS expression through a "],"journal":["Nature plants"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9788986"],"repository":["biostudies-literature"],"pubmed_title":["Dynamic chromatin accessibility deploys heterotypic cis/trans-acting factors driving stomatal cell-fate commitment."],"pmcid":["PMC9788986"],"funding_grant_id":["17H06476","Torii"],"pubmed_authors":["Queitsch C","Seo H","Kim ED","Mitsuda N","Han SK","Torii KU","Dorrity MW","Sepuru KM","Fitzgerald BA"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic chromatin accessibility deploys heterotypic cis/trans-acting factors driving stomatal cell-fate commitment.","description":"Chromatin architecture and transcription factor (TF) binding underpin cell-fate specification during development, but their mutual regulatory relationships remain unclear. Here we report an atlas of dynamic chromatin landscapes during stomatal cell-lineage progression, in which sequential cell-state transitions are governed by lineage-specific bHLH TFs. Major reprogramming of chromatin accessibility occurs at the proliferation-to-differentiation transition. We discover novel co-cis regulatory elements (CREs) signifying the early precursor stage, BBR/BPC (GAGA) and bHLH (E-box) motifs, where master-regulatory bHLH TFs, SPEECHLESS and MUTE, consecutively bind to initiate and terminate the proliferative state, respectively. BPC TFs complex with MUTE to repress SPEECHLESS expression through a ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T17:13:50.31Z","creation":"2025-04-07T04:46:42.138Z"},"accession":"S-EPMC9788986","cross_references":{"pubmed":["36522450"],"doi":["10.1038/s41477-022-01304-w"]}}