biostudies-literatureFabius JHFundação BialRCUK | Biotechnology and Biological Sciences Research CouncilBiotechnology and Biological Sciences Research CouncilFundação Bial (Bial Foundation)7925https://www.ebi.ac.uk/biostudies/studies/S-EPMC9789150biostudies-literatureUnknown13(1)The ability to move has introduced animals with the problem of sensory ambiguity: the position of an external stimulus could change over time because the stimulus moved, or because the animal moved its receptors. This ambiguity can be resolved with a change in neural response gain as a function of receptor orientation. Here, we developed an encoding model to capture gain modulation of visual responses in high field (7 T) fMRI data. We characterized population eye-position dependent gain fields (pEGF). The information contained in the pEGFs allowed us to reconstruct eye positions over time across the visual hierarchy. We discovered a systematic distribution of pEGF centers: pEGF centers shift from contra- to ipsilateral following pRF eccentricity. Such a topographical organization suggests Nature communicationsTopographic organization of eye-position dependent gain fields in human visual cortex.PMC9789150BB/S006605/1A-29315Fabius JHFracasso AMoravkova KfalseTopographic organization of eye-position dependent gain fields in human visual cortex.The ability to move has introduced animals with the problem of sensory ambiguity: the position of an external stimulus could change over time because the stimulus moved, or because the animal moved its receptors. This ambiguity can be resolved with a change in neural response gain as a function of receptor orientation. Here, we developed an encoding model to capture gain modulation of visual responses in high field (7 T) fMRI data. We characterized population eye-position dependent gain fields (pEGF). The information contained in the pEGFs allowed us to reconstruct eye positions over time across the visual hierarchy. We discovered a systematic distribution of pEGF centers: pEGF centers shift from contra- to ipsilateral following pRF eccentricity. Such a topographical organization suggests 2022-01-01T00:00:00Z2022 Dec2025-04-04T08:00:16.347Z2025-04-04T08:00:16.347ZS-EPMC97891503656437210.1038/s41467-022-35488-8