biostudies-literatureUnknown12(6)Chua SKK<h4>Background</h4>The relationship between Parkinson's disease (PD) and coronary artery disease (CAD) is unclear.<h4>Objective</h4>This study aims to investigate whether PD and CAD are associated through systematic review and meta-analysis of observational studies.<h4>Methods</h4>Electronic database search of PubMed, EMBASE, and Web of Science for observational studies published from 1 January 2010 to 1 August 2021 was conducted using terms related to PD and CAD. Unadjusted risk ratios (RR) and odds ratios (OR) of included cohort and case-control studies respectively were used to ascertain the association between PD and CAD. Study heterogeneity was evaluated using the I2 test.<h4>Results</h4>Forty-one full-text studies were initially retrieved for eligibility assessment. Five studies thatJournal of Parkinson's disease1737-1748https://www.ebi.ac.uk/biostudies/studies/S-EPMC9789484biostudies-literatureAssociation Between Parkinson's Disease and Coronary Artery Disease: A Systematic Review and Meta-Analysis.PMC9789484Chua SKKTan EKSaffari SELee SJYfalseAssociation Between Parkinson's Disease and Coronary Artery Disease: A Systematic Review and Meta-Analysis.<h4>Background</h4>The relationship between Parkinson's disease (PD) and coronary artery disease (CAD) is unclear.<h4>Objective</h4>This study aims to investigate whether PD and CAD are associated through systematic review and meta-analysis of observational studies.<h4>Methods</h4>Electronic database search of PubMed, EMBASE, and Web of Science for observational studies published from 1 January 2010 to 1 August 2021 was conducted using terms related to PD and CAD. Unadjusted risk ratios (RR) and odds ratios (OR) of included cohort and case-control studies respectively were used to ascertain the association between PD and CAD. Study heterogeneity was evaluated using the I2 test.<h4>Results</h4>Forty-one full-text studies were initially retrieved for eligibility assessment. Five studies that2022-01-01T00:00:00Z20222025-04-26T09:56:37.992Z2025-04-06T13:09:40.412ZS-EPMC97894843569493610.3233/JPD-223291