biostudies-literatureTian XBeijing Natural Science Foundation Haidian original innovation joint fundBeijing Municipal Administration of Hospitals Incubating ProgramNational Key Research and Development Program of ChinaTraining Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University289https://www.ebi.ac.uk/biostudies/studies/S-EPMC9789633biostudies-literatureUnknown21(1)<h4>Background</h4>The mechanisms linking obesity to cardiovascular disease (CVD) are still not clearly defined. Individuals who are overweight or obese often develop insulin resistance, mediation of the association between obesity and CVD through the insulin resistance seems plausible and has not been investigated. This study aimed to evaluate whether and to what extend the effect of general and central obesity on cardiovascular disease (CVD) is mediated by insulin resistance.<h4>Methods</h4>A total of 94,136 participants without CVD at baseline were recruited from the Kailuan study. Insulin resistance was evaluated by the triglyceride-glucose (TyG) index, calculating as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Mediation analysis using a new 2-stage regression methodCardiovascular diabetologyInsulin resistance mediates obesity-related risk of cardiovascular disease: a prospective cohort study.PMC97896332022YFC36006002022YFC36006032018YFC1312402PX20200212018YFC1312400CCMU2022ZKYXZ009L222123Wang PWang ATian XZhang YXu QWu SLuo YChen SfalseInsulin resistance mediates obesity-related risk of cardiovascular disease: a prospective cohort study.<h4>Background</h4>The mechanisms linking obesity to cardiovascular disease (CVD) are still not clearly defined. Individuals who are overweight or obese often develop insulin resistance, mediation of the association between obesity and CVD through the insulin resistance seems plausible and has not been investigated. This study aimed to evaluate whether and to what extend the effect of general and central obesity on cardiovascular disease (CVD) is mediated by insulin resistance.<h4>Methods</h4>A total of 94,136 participants without CVD at baseline were recruited from the Kailuan study. Insulin resistance was evaluated by the triglyceride-glucose (TyG) index, calculating as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Mediation analysis using a new 2-stage regression method2022-01-01T00:00:00Z2022 Dec2025-04-04T22:36:34.061Z2025-04-04T22:36:34.061ZS-EPMC97896333656477510.1186/s12933-022-01729-9