{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["90(11)"],"submitter":["Nesci S"],"pubmed_abstract":["The c subunits, which constitute the c-ring apparatus of the F<sub>1</sub> F<sub>O</sub> -ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well-known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl-prolyl cis-trans isomerase. On the loop, which connects the two hairpin α-helix of c subunit, is present the unique proline residue (Pro<sub>40</sub> ) that could be a biological target of CyPD. Indeed, the proline cis-trans isomerization might provide the switch that interconverts the open/closed states of the pore by pulling out the c-ring lipid plug."],"journal":["Proteins"],"pagination":["2001-2005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9790210"],"repository":["biostudies-literature"],"pubmed_title":["Protein folding and unfolding: proline cis-trans isomerization at the c subunits of F<sub>1</sub> F<sub>O</sub> -ATPase might open a high conductance ion channel."],"pmcid":["PMC9790210"],"pubmed_authors":["Nesci S"],"additional_accession":[]},"is_claimable":false,"name":"Protein folding and unfolding: proline cis-trans isomerization at the c subunits of F<sub>1</sub> F<sub>O</sub> -ATPase might open a high conductance ion channel.","description":"The c subunits, which constitute the c-ring apparatus of the F<sub>1</sub> F<sub>O</sub> -ATPase, could be the main components of the mitochondrial permeability transition pore (mPTP). The well-known modulator of the mPTP formation and opening is the cyclophilin D (CyPD), a peptidyl-prolyl cis-trans isomerase. On the loop, which connects the two hairpin α-helix of c subunit, is present the unique proline residue (Pro<sub>40</sub> ) that could be a biological target of CyPD. Indeed, the proline cis-trans isomerization might provide the switch that interconverts the open/closed states of the pore by pulling out the c-ring lipid plug.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T21:00:54.201Z","creation":"2025-04-04T21:00:54.201Z"},"accession":"S-EPMC9790210","cross_references":{"pubmed":["35532281"],"doi":["10.1002/prot.26383"]}}