biostudies-literatureUnknown39(12)Safrai M<h4>Purpose</h4>To assess the feasibility, effectiveness, and reproductive outcomes of transplantation of tiny cryopreserved ovarian pieces through a pipelle cannula during laparoscopic surgery.<h4>Methods</h4>A retrospective study of patients who underwent ovarian tissue transplantation for fertility restoration between 2004 and 2022. The "pipelle group" had their ovarian cortex cut into tiny pieces of ~ 1-2 mm³ before cryopreservation. The pieces were too small to be handled and transplanted via standard laparoscopic tools. Transplantation was performed using a pipelle cannula during laparoscopic surgery. The "control group" underwent transplants of ovarian cortex pieces 1-2 mm thick, measuring approximately 25-50 mm² pieces, using standard procedures.<h4>Results</hJournal of assisted reproduction and genetics2827-2834https://www.ebi.ac.uk/biostudies/studies/S-EPMC9790840biostudies-literatureTransplantation of small ovarian tissue fragments using pipelle device is effective: method evaluation and reproductive outcomes.PMC9790840Raanani HShapira MShai DAizer AStockheim DMeirow DSafrai MTsur AfalseTransplantation of small ovarian tissue fragments using pipelle device is effective: method evaluation and reproductive outcomes.<h4>Purpose</h4>To assess the feasibility, effectiveness, and reproductive outcomes of transplantation of tiny cryopreserved ovarian pieces through a pipelle cannula during laparoscopic surgery.<h4>Methods</h4>A retrospective study of patients who underwent ovarian tissue transplantation for fertility restoration between 2004 and 2022. The "pipelle group" had their ovarian cortex cut into tiny pieces of ~ 1-2 mm³ before cryopreservation. The pieces were too small to be handled and transplanted via standard laparoscopic tools. Transplantation was performed using a pipelle cannula during laparoscopic surgery. The "control group" underwent transplants of ovarian cortex pieces 1-2 mm thick, measuring approximately 25-50 mm² pieces, using standard procedures.<h4>Results</h2022-01-01T00:00:00Z2022 Dec2025-04-21T23:07:57.147Z2025-04-05T19:04:26.175ZS-EPMC97908403641861710.1007/s10815-022-02652-4