{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["De Smet MAJ"],"pubmed_abstract":["Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury. Diagnostic work up showed a hyperinflammatory syndrome, hypertriglyceridemia, hemophagocytosis, very high ferritin and significantly elevated sCD25. The findings were compatible with hemophagocytic lymphohistiocytosis based on the HLH-2004 criteria. Serological testing indentified <i>Puumala virus</i> as the causal pathogen. The patient was successfully treated with pulse corticosteroids, intravenous immunoglobins and supportive therapy."],"journal":["Frontiers in medicine"],"pagination":["1096900"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9790895"],"repository":["biostudies-literature"],"pubmed_title":["Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis."],"pmcid":["PMC9790895"],"pubmed_authors":["Bogaert S","Schauwvlieghe A","De Smet MAJ","Dendooven A","Druwe P","Depuydt P"],"additional_accession":[]},"is_claimable":false,"name":"Case report: Hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis.","description":"Hemophagocytic lymphohistiocytosis may occur in patients with genetic predisposition and in sporadic cases due to malignancy or infection. We describe a 49-year old man with hemorrhagic fever, type 1 respiratory insufficiency and acute kidney injury. Diagnostic work up showed a hyperinflammatory syndrome, hypertriglyceridemia, hemophagocytosis, very high ferritin and significantly elevated sCD25. The findings were compatible with hemophagocytic lymphohistiocytosis based on the HLH-2004 criteria. Serological testing indentified <i>Puumala virus</i> as the causal pathogen. The patient was successfully treated with pulse corticosteroids, intravenous immunoglobins and supportive therapy.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T13:09:52.591Z","creation":"2025-02-19T04:42:56.308Z"},"accession":"S-EPMC9790895","cross_references":{"pubmed":["36579154"],"doi":["10.3389/fmed.2022.1096900"]}}