{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(12)"],"submitter":["McGrath FM"],"funding":["Food Allergy and Anaphylaxis Network","Royal Perth Hospital Medical Research Foundation","Australian Genome Research Facility"],"pubmed_abstract":["<h4>Objective</h4>Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by investigating gene expression changes.<h4>Methods</h4>Microarray data set GSE69063 was analysed, describing emergency department (ED) patients with severe anaphylaxis (<i>n</i> = 12), moderate anaphylaxis (<i>n</i> = 6), sepsis (<i>n</i> = 20) and trauma (<i>n</i> = 11). Samples were taken at ED presentation (T0) and 1 h later (T1). Healthy controls were age and sex matched to ED patient groups. Gene expression changes were determined using <i>limma</i>, and pathway analysis applied. Differentially expressed genes were validated in an independent cohort of anaphylaxis patients (<i>n</i> = 31) and matched healthy controls (<i>n"],"journal":["Clinical & translational immunology"],"pagination":["e1435"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9791329"],"repository":["biostudies-literature"],"pubmed_title":["Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans."],"pmcid":["PMC9791329"],"pubmed_authors":["McGrath FM","Macdonald SP","Woo AJ","Francis A","Arendts G","Bosio E","Fatovich DM"],"additional_accession":[]},"is_claimable":false,"name":"Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans.","description":"<h4>Objective</h4>Mechanisms underlying the anaphylactic reaction in humans are not fully understood. Here, we aimed at improving our understanding of anaphylaxis by investigating gene expression changes.<h4>Methods</h4>Microarray data set GSE69063 was analysed, describing emergency department (ED) patients with severe anaphylaxis (<i>n</i> = 12), moderate anaphylaxis (<i>n</i> = 6), sepsis (<i>n</i> = 20) and trauma (<i>n</i> = 11). Samples were taken at ED presentation (T0) and 1 h later (T1). Healthy controls were age and sex matched to ED patient groups. Gene expression changes were determined using <i>limma</i>, and pathway analysis applied. Differentially expressed genes were validated in an independent cohort of anaphylaxis patients (<i>n</i> = 31) and matched healthy controls (<i>n","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T15:53:20.331Z","creation":"2024-10-17T22:07:39.393Z"},"accession":"S-EPMC9791329","cross_references":{"pubmed":["36583159"],"doi":["10.1002/cti2.1435"]}}