biostudies-literatureGibbons CHorizon 2020 Framework ProgrammeSteno Diabetes Center Copenhagen (SDCC)SWEETe063903https://www.ebi.ac.uk/biostudies/studies/S-EPMC9791453biostudies-literatureUnknown12(12)<h4>Introduction</h4>Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes.<h4>Methods and analysis</h4>A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five foodBMJ openAcute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project.PMC9791453SDCC 3.G774293Kjolbæk LBlaak EERaben AHarrold JAScott CNormand MAlligier MFeskens ERannou CMartinez JAFinlayson GWilton MNavas-Carretero SMoshoyiannis HBeaulieu KNazare JAHalford JCGGibbons CO'Hara BO'Connor DHardman CHodgkins CEAlmiron-Roig EfalseAcute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project.<h4>Introduction</h4>Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes.<h4>Methods and analysis</h4>A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food2022-01-01T00:00:00Z2022 Dec2026-07-14T16:06:11.873Z2024-11-19T17:02:42.46ZS-EPMC97914533656411410.1136/bmjopen-2022-063903