{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amado-Rodriguez L"],"funding":["Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología","Centro de Investigación Biomédica en Red","Instituto de Salud Carlos III","Health Research Board"],"pagination":["55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9791731"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality.<h4>Methods</h4>Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model.<h4>Results</h4>From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77"],"journal":["Journal of intensive care"],"pubmed_title":["Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study."],"pmcid":["PMC9791731"],"funding_grant_id":["CM20/00083","ECSA-2020-009","AYUD2021/52014","CB17/06/00021"],"pubmed_authors":["Foti G","Curto EG","Pillai S","Meybohm P","Laffey JG","Hraiech S","Montini LM","Lovazzano P","Ling LL","Watanabe E","MacFie CC","Simonis FD","Aker M","Schioler F","Di Tomasso NN","Treanor N","Hurtado J","Dolva MS","Noremark KAL","Albarrak MM","Bhowmick K","Cardonnet LP","Scafetti S","Bulpa PA","Santos C","Bajwa E","Andruszkiewicz P","Vercueil A","Trinidad OA","Lopez-Messa J","Villar V","Yu R","Amir F","Dangers L","Shenoy A","Estrella CR","Ruiz SR","Mukkera SR","Riss KC","Maca J","Kakar V","Borello SA","Yu W","Yu T","Namih M","Abroug F","Aisiku I","Cerny V","Palaniswamy V","Fossali T","Nishikawa E","Cereijo E","Uchiyama A","Declercq PM","Papavasilopoulou TG","Lombardo A","Gonzalez DR","Azevedo LC","Garcia PH","Schuetz M","Ricome S","Nunomiya S","Ourailogloy V","Mckechnie S","Estilita JM","Krstevski A","Oldroyd MG","Welters ID","Haddad Y","Schouten JA","Jha RR","Preez P","Hagan S","Arabi YM","Boyd O","Unal N","Chiche JD","BannerGoodspeed VM","Stigler W","Chen K","Kennedy B","Combes A","Bauer PR","Oneill O","Pittini G","Schlichting AB","Jaafar RF","Abe T","Deicas A","Casement J","Leemann-Refondini C","Nasu M","Biondi RS","Cracchiolo AN","Mancebo J","Pota V","Mojoli F","Zogheib EH","Perez C","Cirone R","Blanco J","Macfadyen R","Perez M","Allue RM","Sellors GP","Dowling A","Hedlund L","Loiacono FA","Coppadoro A","Rosa J","Schiavoni L","Okane SC","Casalena P","Higashijima U","Jakubowska K","Tiribelli N","Dean M","Rodgers HJ","Shen J","Zantua CKS","Castro S","Pecci E","Mataloun S","Nin N","Jassal M","de Prost N","Toth-Tarsoly P","Alvarez AM","Gosselin RJ","Insaurralde CS","Beloncle F","Zhu WH","Nagy EO","Hutton P","Javeed A","Bisso MC","Vermassen J","Setten MG","Heidari F","Vargas MP","AlJabbary A","Molin A","Wong HS","Virgilio C","Nunes S","Mercat A","Oikonomou MA","Han Y","Mirabella L","Cole J","Qin SH","Villagomez A","Chau S","Beitler JR","Schneider F","Thomas M","Negoita SI","Jochmans S","Gomaa D","Piras C","Diaz JCJS","Barratt-Due A","Tabhan E","Uppalapati A","Lohner R","Bouchoucha S","Braschi A","Kong J","Persson L","Black C","Phan NT","Raaijmakers M","Oliveira BS","Han H","Newby L","Poblano M","Aguirre JS","Mejia FJF","Esteve F","Patroniti N","Villamagua B","Zein SO","Bailey MB","Todeschini M","Biehler J","Daviaud F","Tan BC","Briquet A","Twohey L","Cranshaw J","Soreide E","Al Dorzi HM","Qin TH","Balkhi H","Besset SL","Tainter C","Takada T","Taylor Thompson B","Michel P","Occhipinti G","Alfonso AAT","Pasanting-Lim RAB","Bihari S","Farias PA","Hacking D","De Pablo R","Doyen D","Dixit SB","Rhayakar R","Del CarmenLorente M","Aguilar RZ","Matsumoto S","Aneman A","Burtin P","Schiavone V","Kadaba V","Shah B","Zani G","Cervantes MR","Bailey IM","Bhardwaj V","Ghazi M","Soler JA","McCalman K","Stephenson L","Gonzalez M","Nygren I","Goncalves CH","Ibanez-Santacruz M","Sagar SV","Williams KE","Palo JE","Sanchez-Medina JR","Badie JC","Sher S","Guttormsen A","Schafer S","Hopf HF","Breen DM","Andoh K","Wang HX","Rojas A","Elisabet GM","He Z","Citalan JE","Ceniceros-Barros A","Alonso JG","Carteaux G","Avila LE","Choudry S","Beduneau G","McKenna TE","Memon M","Volta CA","Cesar PS","Fan E","Cortez CA","Graziani R","Robine A","Zhao XY","Li B","Donnelly A","Herbrecht JE","Ogino Y","Ranieri M","Collins DV","Yuste LJ","Srinivasa L","Honda H","Davies KG","Arabi Y","Helleberg J","Albaiceta GM","Laake JH","Para LH","Follin A","Arizmendi A","Hashida T","Qiu H","Vinzio M","Amor M","Takagi S","Vega LD","Kraßler J","Pattarino I","Canestrini S","Muthuchellappan R","Maghrabi KA","Bruns MM","O'Muircheartaigh AC","Hunt A","Watt P","Mehta S","Van Haren F","Bolon S","Dreyer KR","Azad R","Gomes RM","Dawson H","May MM","Li Q","Ichikado K","Botteri M","Gianinetto H","Li W","Li X","Li Y","Ioannou N","Dive AM","Daubin C","Baronia AK","Pellicer AM","Piquilloud L","Lora P","Jiang L","Izawa M","Lemus JS","Christiansen A","Scott C","Wessbergh J","Matamis D","Arnal JM","Nutt C","Samkaoui N","Gao YN","Aliaga FA","Navarro G","Maeyama HN","Demirkiran O","Nielsen J","Collyer T","Careless JP","Fierro JM","Gordo F","Roberts BL","Niimi D","Dempsey G","Ajetunmobi OO","Derman S","Hormis AP","Imperio MC","Franco N","Pereira CS","Nunci L","Sanchez-Hurtado LA","Nobrega D","Lorente JA","Thompson M","Castro AG","Luo X","Sauvadet E","Forteza C","Zhang F","Raj AS","Beegle SH","Lopez-Delgado J","Morin AK","Albiero D","Floris L","Magret M","Isidro S","Pronovost A","Gritsan AI","Poli MM","Claverias L","Kajtor I","Li QJ","Beck O","Zheng R","Beck E","Parotto M","Dector D","Smith MJ","Tibblin AO","Mcleod A","Alda RS","Amado-Rodriguez L","Kheir F","Seethala R","Millar RT","Souissi AB","Lamb KD","Kheir FM","Williams AJ","Shiozaki K","Hopkins P","Akyol O","Monteiro JM","Antonelli MM","Fartoukh M","Zhou S","Gattinoni L","Terragni P","Xin-Hua Q","Batra H","LeonYoshido HH","Reske AW","Vitale MN","Amin P","Wenham T","Szakmany T","Knoll J","Broman LM","Laffey J","Alejandro RV","Wu YQ","Mckee R","Camsooksai J","Nunez E","Almekhlafi G","Sanchez-Ballesteros J","Huerta F","Gillis S","Temprano S","Baboi L","Sun R","Chelly J","Rinia M","Schultz MJ","Zhu BH","Umbrello M","Roux D","Rigaud JP","Jurado MT","Richecoeur JR","Ramesh VJ","Kannan SG","Ismail M","Gazenkampf AA","Delsing A","Kameyama Y","Ismail D","Knowles S","Imma VP","Dwyer R","Goligher EC","Sjobo B","Baltus T","Kurahashi K","Rodriguez R","Las Lomas S","Albaiceta G","Tinnirello A","Kalkoff M","Vasquez DN","Sim M","Reuter D","Erbabacan E","Bezzi MG","Olga MF","De Cima-Iglesias S","Moock M","Zacharas GA","Recio N","Kumar A","Chabanne R","Brown S","Yeatts D","Saito S","Li XL","Saito K","Kitch BT","McArthur C","Humphreys SK","Pozzi M","Andersen FH","Goldgran-Toledano D","Robles JB","Le Moal C","Tabhan EE","Futami S","Brizuela M","Luis PSE","Colombo R","Strauch U","Combaux D","Xu Y","Brito VA","Savioli M","Sanchez RM","Liu JL","Zacharowski KD","Grelon F","Saez AA","Antonio ACP","Montero LA","Barros FM","Elmasri M","Bumbasirevic V","Cerrato VI","Staudinger T","Dunne E","Morton A","Frigyik AD","Ramirez-Gutierrez A","Bedreag OH","Mesar T","Lebbinck H","Mohr NM","Kusumoto K","Nassar AP","Goodson JC","Gomez-Flores SS","Oetting TW","Toribio DP","Moya DDL","Abad RD","Reynolds C","Koyama K","Honrubia T","Jimenez JIS","Kamoun S","Barros NC","Dupont H","Kiourtzieva EV","Carbayo-Gorriz C","Ellis H","Harrois A","Kulkarni S","Lora FS","Vascotto E","Jarquin-Badiola Y","Eriksson K","Iotti GA","Sanchez RJ","Sottiaux T","Nakamura T","Pesenti A","Ferguson ND","Chouchene I","Liu H","Liu J","Liu L","Rugonfalvi S","Frati E","Barberet G","Aguirre-Bermeo H","Jibaja M","Saenz MG","Bugedo G","Brazzi L","Ezzouine H","McNamee L","Namendys-Silva SA","Buzancais G","Girgin NK","Li YY","Bramall J","Bouw MJ","Elatrous S","Estenssoro E","Cheng MP","Grigoriev E","Shinn Iii JO","Gomez PE","Seasman C","Miller RR","Fernandez RO","Tulaimat A","Tomescu DR","Whitehead C","Ilutovich S","Berghe C","Schomer A","Martinho AM","Cooper R","Stamou EE","Artigas A","Manoharan V","Hua MX","Allan RM","Pham T","Alisasis AU","Franca AG","Sales VM","Slutsky AS","Roser TP","Kimura H","Symmonds S","Demoule A","Mustafa GM","Boukhazna M","Mortaza S","Neal J","Raimondi F","Osman EM","Palmese S","Danin PE","Marum SM","Burtenshaw AJ","Ascoli A","Pelletier N","Thibault S","Massa EV","Liew KY","Dempaire G","Woods PW","An Y","Coxo CM","Seven A","Gonzalez-Salamanca A","de Gordoa LO","Stewart R","Grissom C","Daldin J","Rampinelli AM","Giarratano A","Van Wezel HM","Khebbeb S","Altaf W","Dendane T","Dres M","Terzi N","Brochard L","Zeggwagh AA","Larsson N","Ortiz CA","Marin MC","Rodriguez-Garcia R","Glietsch R","Cazorla-Barranquero FG","Sula H","Hanlon GC","Lemiale V","Elkhayari M","Zhang XY","Hessell RJ","Yao Q","Biscione R","Dellamonica J","Montanha GM","Larsson A","Ye ZL","Gao Y","Protti A","Meersseman P","Sable SD","Rubenfeld G","Reschreiter H","Huang QQ","Llano I","Hashemian SM","Alexander P","Zhai Z","Bigot C","Shimizu K","Carpentier D","Yumha JS","Crouch DR","Nichol A","Gurjar M","Adams JC","Oscanoa FAM","Grubissich N","Wittebole X","Smith O","Chapman R","Curley G","Miller JJ","Gueret RM","Holzgraefe B","Warren J","Salas JE","Hang AY","Dellera C","Papurica M","RocheCampo F","Rios F","Tarantino F","Csabi P","Hou PC","Huang XB","Algaba A","Mouloudi EK","Zhou FC","Sklienka P","Willett E","Rodriguez LL","Lynch JM","Rossi A","Ferguson A","Rafael SI","Marcos DP","Griffin RO","Zender H","Piacentini EA","Mochizuki K","Ramakrishnan N","Brunettini B","Wrathall DW","Huff NG","Kashiwa Y","Navarra L","Catorze N","Owens R","Papanikolaou MN","PrietoGonzalez M","Appelberg H","Berkelmans F","Blakeman TC","Zhao J","Buensuseso JA","Ozcelik M","Zhao H","Beuret P","Aisa TM","Aoki N","Raponi F","LUNG SAFE investigators","Frendl G","Kamel G","Silesky J","Cimic N","Salahuddin N","Yamaji Y","Bruhn AR","Ranero JL","Mattei A","Meco BC","O'Croinin D","Tapponnier R","Bettini LR","Ueno K","Mizuguchi I","Jovanovic B","Heunks LM","Venti A","SolisQuesada JE","Clarkson K","Tanaka H","Hou SK","Gelee B","Baro RM","Monti G","Okuda N","Adamsson RO","Parhar K","Cortegiani A","Lanspa M","Santoli F","Seoane-Quiroga L","Madotto F","Sabelnikovs O","Hutchison RA","Artiga MJD","Pintado MC","Cinnella G","Penuelas O","Moles SI","Irvine D","Adolfsson A","Esteban A","Bumbasierevic V","Cohen JE","Ebeid A","Fernandez AM","Suzuki H","Unnikrishnan R","Beraldo DO","Kander T","Knapman KM","Messika J","Benslama A","Rialp G","Alvarez J","Verstraete R","Hadfield D","Chena A","Palma DM","Corneci DE","Navalpotro MAB","Ueda T","Goubaux B","Plotnikow GA","Battle CE","Clarkson KP","Ceylan I","Panarello G","Takaba A","van Haren F","Ceunen H","Rittayamai N","Gjedsted J","Losada EP","Fontenele DC","Kol MR","Kedelv H","McAuley D","Jog SA","Duranteau J","Hermosa C","Diaz-Rodriguez E","Imai H","De Haro C","Depuydt P","Harasawa T","Araujo A","Crapelli G","Fusari M","Henderson G","Ramirez-Alfaro C","Nitta K","Browne TS","do Vale Fernandes A","Shao H","BinHJAbul Wahab AY","Cani A","Shindhe S","Crova PJ","Qin J","Zazu A","Lopez EB","Lee J","Wrigge H","Messias AM","Claraco-Vega L","Martinez FT","Labarca EF","Tang R","Ryosuke S","Li-Xin Z","Rylander CC","RuizAguilar A","Ganesan D","Borotto EE","Marcu A","Buise MP","Marin J","Sivashanmugavel M","Pellegrini CA","Carreno NG","Kalaitzis E","Qin B","Simon P","Lu W","George FG","Judy C","Lu Y","Wang C","Hirata A","Pozo NC","Di YD","Spadaro S","Ito F","Wang S","Wang W","Maazouzi W","Mahto H","Serra I","Inskip DM","Serra C","Trinder TJ","Gally J","Gonzalez RM","Bellani G","Heines SJ","Guerin C","Jamaati H","Fawkes DA","Papazian L","Oss P","Yamaguchi O","Formenti P","Meaney EA","Sandesc D","Jimenez A","Ouanes I","Mellis C","Gomez PRA","Rojas MAG"],"additional_accession":[]},"is_claimable":false,"name":"Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study.","description":"<h4>Background</h4>Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality.<h4>Methods</h4>Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model.<h4>Results</h4>From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-07-14T15:52:13.736Z","creation":"2024-11-09T20:34:04.519Z"},"accession":"S-EPMC9791731","cross_references":{"pubmed":["36567347"],"doi":["10.1186/s40560-022-00648-x"]}}