{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen H"],"funding":["National Natural Science Foundation of China-Guangdong Joint Fund","National Natural Science Foundation of China"],"pagination":["101604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9792398"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28"],"pubmed_abstract":["Circular RNAs (circRNAs) have been demonstrated to be important regulators in human malignant tumors, including colorectal cancer (CRC). While the role circ-ZEB1 played in CRC remains unclear. In this study, we aim to explore the biological function and the underlying mechanism of circ-ZEB1 in CRC. RNAscope was used to analyze the expression and localization of circ-ZEB1 in CRC tissues. Loss of function experiments were conducted, including CCK-8, transwell assays, flow cytometry analysis, and murine xenograft models, so as to detect the effect of circ-ZEB1 on CRC cells. IC50 assay was used to evaluate the influence of circ-ZEB1 on the chemoresistance of CRC cells. Epithelial-mesenchymal transition (EMT) related markers were detected. The relationship between circ-ZEB1 and miR-200c-5p was "],"journal":["Translational oncology"],"pubmed_title":["circ-ZEB1 regulates epithelial-mesenchymal transition and chemotherapy resistance of colorectal cancer through acting on miR-200c-5p."],"pmcid":["PMC9792398"],"funding_grant_id":["82002471","81802353"],"pubmed_authors":["Li Y","Yang L","Zhang J","Ye C","Chen H","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"circ-ZEB1 regulates epithelial-mesenchymal transition and chemotherapy resistance of colorectal cancer through acting on miR-200c-5p.","description":"Circular RNAs (circRNAs) have been demonstrated to be important regulators in human malignant tumors, including colorectal cancer (CRC). While the role circ-ZEB1 played in CRC remains unclear. In this study, we aim to explore the biological function and the underlying mechanism of circ-ZEB1 in CRC. RNAscope was used to analyze the expression and localization of circ-ZEB1 in CRC tissues. Loss of function experiments were conducted, including CCK-8, transwell assays, flow cytometry analysis, and murine xenograft models, so as to detect the effect of circ-ZEB1 on CRC cells. IC50 assay was used to evaluate the influence of circ-ZEB1 on the chemoresistance of CRC cells. Epithelial-mesenchymal transition (EMT) related markers were detected. The relationship between circ-ZEB1 and miR-200c-5p was ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-21T15:22:23.904Z","creation":"2025-04-21T15:22:23.904Z"},"accession":"S-EPMC9792398","cross_references":{"pubmed":["36542990"],"doi":["10.1016/j.tranon.2022.101604"]}}