{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holman RR"],"funding":["NHLBI NIH HHS"],"pagination":["1228-1239"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9792409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["377(13)"],"pubmed_abstract":["<h4>Background</h4>The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.<h4>Methods</h4>We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy.<h4>Results</h4>In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular dis"],"journal":["The New England journal of medicine"],"pubmed_title":["Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes."],"pmcid":["PMC9792409"],"funding_grant_id":["T32 HL069749"],"pubmed_authors":["Dzupina A","Kaczmarek G","Armaganijan L","Choi KM","Pillai P","McGill J","Flanagan T","Boggs B","Pastare S","Merrick B","Koshelskaya O","Ebrahim I","Czegany Z","Zrahevskiy K","Ferrier N","Riddle M","Yuan Z","Sulskiene M","Genovese S","Ranjith N","Dang C","McKnight J","Busch R","Nirmalaraj K","Busch K","Hodi G","Barros P","Rouleau JL","White J","Leiva-Pons JL","Gonzaga C","Akinboboye O","Hoogslag PAM","Kovacheva S","Califf RM","Kuritsky R","White A","Tse HF","Reicher B","Cheung-Wong MM","Wilhase 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without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy.<h4>Results</h4>In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular dis","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-10T05:07:57.217Z","creation":"2025-04-04T12:09:52.705Z"},"accession":"S-EPMC9792409","cross_references":{"pubmed":["28910237"],"doi":["10.1056/nejmoa1612917","10.1056/NEJMoa1612917"]}}