biostudies-literatureHolman RRNHLBI NIH HHS1228-1239https://www.ebi.ac.uk/biostudies/studies/S-EPMC9792409biostudies-literatureUnknown377(13)<h4>Background</h4>The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.<h4>Methods</h4>We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy.<h4>Results</h4>In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disThe New England journal of medicineEffects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.PMC9792409T32 HL069749Dzupina AKaczmarek GArmaganijan LChoi KMPillai PMcGill JFlanagan TBoggs BPastare SMerrick BKoshelskaya OEbrahim ICzegany ZZrahevskiy KFerrier NRiddle MYuan ZSulskiene MGenovese SRanjith NDang CMcKnight JBusch RNirmalaraj KBusch KHodi GBarros PRouleau JLWhite JLeiva-Pons JLGonzaga CAkinboboye OHoogslag PAMKovacheva SCaliff RMKuritsky RWhite ATse HFReicher BCheung-Wong MMWilhase ALitchfield JZimmerman RAizenberg DFulop TMehling HHsieh ICVincent JLehrke MAomar ICignarelli MWine ANiegowska JMah PMDong YHenson BAronoff SCruciani AIvanov VDunn PNothroff JHassan MRAMumtaz LHatheway RCavale 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HJWeng JStasinksa TDenham DTivadar SPieber TWebster BSchnack CTeterovska DPopa ARDamyanova VCorder CGrabowska AClaxton EHarrison RNadar VMorse MChoi JFoo SHMosenzon OOldenburg-Ligtenberg PCHavelkova JTan ATBaldauf CPauker ZKleinertz KAngustias Quesada MGarbelini BMurin JGu WJi LKhan ASherenkov AKovacs AGraves MUrina Triana MShah BMolnar MYong HPanina SBecker BAkerblom ATisch ADimitropoulos IKhan SPeden EKrami PEl Shahawy MKopytsya MDe La Garza Hernandez NEGoodman HBloomfield GKuesters DRheeder PLopes Rde Valk HWGoodman SWoo VWright ATseluyko VLottering HVaranauskiene EKatz MZinman BAlcocer Gamba MATsao JRaffo CEapen ZZaidman CDelcourt CHyland KMathieu CLai WTGeorge JOng TKSperl-Hillen JZaluska RCarim-Ganey NKentgens SGeorge DKim ESHoogendyk JNicol PGolden GRamachandran ATurova ESorli CSamoylova YMaxwell SMazza GBlumberg EPeterfai EPhilip SSigal RJakuboniene NCanadas RLouw CSchaufele TJaffe ASaraiva JKVinanska DRizvi SPerez Amador GDuengen HDRepin AGreen SSeissler JGomez Marcos MAShanik MMehta PMehta RBernandez SKim CJMcNeill RRohatgi Avan Kempen WWLippai JDezso EBenson MMaffei LNafornita VNicodemus NKirby WPurewal TYakov AVandorfi GAzad NConstantinescu SLi QTamez Perez HEAdler AKlyver MIKung KDe La Fuente RLLi YRobbins DSritara PFishman NMasterson MDreval ALinn TRamanathan LOparil SJones SDayamani PGustavson SMFulat MSchnall ABain CCoetzee KScott RTsang CCFarnsworth KJackson BWysham CJackson LProietto JUkwade PJackson RChadha CHeller SLevterov GForce RSoule JLuo NMirasoi RBerenfus VThompson NSerne EHKlainman ELevchenko OLarson DClark JWilson SWong YWWilson JZhang LWilson MCoronel Arroyo JBrychta TLucas KPererva LHissa MZazula ACheung BMPrager RMisterski JKerr JMarso SPVonderHaar TMirecka HElias NLook MCaterson IWoodall AGaal ZDiamant MStruble RDavies MPearce MGushterova VHomenda WIzmozherova NFrancesconi CMikell FHargrove JSantibanez CMandawat ATillmann HOh BHPaz Pacheco ESattar NPryke JMorawski EEstevez RDurborow LCustodio MYeung VTYan BPYCalella PVishlitsky VZhou SClausen EBatra PCosta e Forti ALeiter LAron GMincheva LSaban JBatit MCutfield RSimpson HPanelo AGreen JBKoval OMcDermott MKumar SColman PHiggins AVillarino AHermes SHeadapohl DOvercash JVlasenko MWade TAngelescu LMTan FSimon-Wagner IUrbanaviciene EYang TBhatt BTan RPantikova KPogorzelska HKose VSchipperen SWhitehouse FPalinkas AMarasaev VBickel LGandy WOrozco Linares AGorelick FSalvioni ARose LChan JCWing JDreval AVLabroo ALeitane IRobitaille YObrezan ACoetzer TRoque FBorges JLeBlanc TPaulweber BMediavilla Garcia JLaferrere BPozzi EStrautina IDetweiler RCarr KHage-Korban EPohl WIlliev DMolina de Salazar DIJimeno CRassouli NSiu DCBarrientos Perez MMu YRim SJFeng YSilwinska TFisher NSanders KCalvert JCylkowska BBondar ILeonardi SSuplotova LPadayachee TRodbard HManos PNardone LRoss SGaudiani LTaller AJaffer SDe Souza Brito FGallegos JAPiepiorka MKarounos DMilward ASeyoum BJunbo GTschope DKruger DLopes SMSu SLReed JVoros PQuinn DRoseman HRojas-Lingan GMacrury SThompson VPDeVore AGagel RZaharieva SFarago Kdel Prato SPaul PDu YBezzegh KBashkin APei DEliaschewitz FVendrell Ortega JDugano-Daphnis PVo AMcGuire DPozzilli PAng EDavis CGrishyna OKesmarki NHeal PTeliatnikova ZForst TYale JFEllis GWeiss DWoodford TGilbert JAlvarisqueta AMarin CREXSCEL Study GroupPenzes JDistiller LCulman MILiu LShimon IVayda MSanchez Mijangos JHAcheatel RStalte VLecube ASwinkels-Diepenmaat LDungan KPfutzner AWeiss RPandey ADanyte EOelbaum RDushkin HLedesma GArguelles IAlfonso LD’Agostino RLovasz OFedacko JFasching PPunthakee ZStout EAkpunonu BFerch ALiu DUlla MREbo GGuo XVelaviciene ADrexel HStevlik JRazzaque NAl-Khatib SSugimoto DEckel RBieler TManning MBMoran JKelfkens YMlitaru CGreenspoon AFox DBressler PTaylon AHalim SBellary SDiGiovanna MArauz-Pacheco CKuskalo PStern NMulford MStrongin LBartolacci IBandeira e Farias FSoler NTirador LGiep SDauksiene DBlignaut SOsunkoya ASellers MALevinger ADarbyshire JSevera LReaven PQu SSzakal ICheung SChang ASelecky JFushtey IMcMurray JLuk AOYDombrowski 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MButnaru AFrechtel GWittman IChu DWEbenbichler CDixon PKamke WNseir WNicolau JBajaj MBadat ASoufer JZeitler EOerter EMWong SYSHamer APhilippiova ASchactman BMindrescu NMCohen JKravitz ADogadin SGosselin GSwart HBraun MTakacs JHanefeld MNortje HGelersztein Evan Bemmel BNamgung JOkopien BLenhard JZilahi ZMacFarlane DSzilagyi IDulin MTytus RMoon SMaslyanko VKerenyi ZPotthoff SVatutin MMeadows YSroka MGraur MGrunberger GLefterov INMogashoa SGottlieb PLewis BLasiene JSowinski DRassi NChaudhri OTinahones FJVacaru GWakefield PBarkai LChacra AUrbanavicius VErickson BBiscoveanu MTahk SJDenopol MSchellong SOulhaj ABell AAlvarez LKilvert AHernandez AFAnoop MTripathy DHidalgo HMaggioni APPagidpati Nde Salvo MAlmeida CABethel MARamirez Diaz SPLee WYJaramilo Gomez CJKellinerova ICure Cure CASathayapalan TGodoy JMilek KShort BBland VVilleda Espinosa EColeman RMartynyuk LToth PJeffries WPles ZLanders BGellad ZPupek-Musialik DBuganova ILisboa HKrebs JSauque Reyna LSheinkova GLarin OFuto LAdamkova VEaton COral ESheu WBhargava AMahabadi VMugge AVoors-Pette CRoe MKis JTPowell SThissen JPAndersone IPowell TAguliera DIlieva ESeedat SKhokhlov ALokhnygina YHung YJSchernthaner GKingsley JSchoper FPrice DBenjasuratwong YRudyk ISimon JGuimaraes PKayne DGhani RAMunteanu MLinong JWang JOroszan TPosvic TWiles PHernandez Triana ESmolenskaya OBarber THerring CWang YLeese GBental TPella DGyrina OTseng STAugusteniene AArgoud GSigalas JSoto ABotsyurko VAsamoah-Owusu NJSchubart UPahl JHoppichler FLuger ASosovec DCheah WKKakariekiene VLagzdina LStelmane IRadbill MAmerena JPrysupa LNikitov ZKim YNAppel KFTorello ALHian SKOmar MRasouli NBaron MBotella Serrano MKessel JStaniloae CJimenez ASokolova LBoenninghoff AHSokolova JElkins MReiber IMileder MNam CWCampbell COlexa PfalseEffects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.<h4>Background</h4>The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.<h4>Methods</h4>We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy.<h4>Results</h4>In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular dis2017-01-01T00:00:00Z2017 Sep2026-05-10T05:07:57.217Z2025-04-04T12:09:52.705ZS-EPMC97924092891023710.1056/nejmoa161291710.1056/NEJMoa1612917