{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Benitez J"],"pubmed_abstract":["<h4>Background</h4> Thymic epithelial tumors (TETs) are rare malignancies of the anterior mediastinum with a high histopathological diversity from thymoma A to thymic carcinoma (TC). The biology of TETs is poorly understood and knowledge of the transcriptomic fingerprint of thymoma and TC is limited. Up to 30% of patients will develop associated autoimmune disorders, mainly myasthenia gravis (MG). We aimed to characterize main cancer activation pathways of TET subgroups. <h4>Methods</h4> We selected a representative balanced set of thymoma and TCs to analyze 24 main cancer activation pathways using gene expression throughout Oncology biomarker panel (2,562 genes). Tumor representative paraffin-embedded blocks were macrodissected. Then, we merged data with The Cancer Genome Atlas (TCGA) dat"],"journal":["Mediastinum (Hong Kong, China)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9792825"],"repository":["biostudies-literature"],"pubmed_title":["AB008. Activated pathways of Thymic Epithelial Tumors: a RYTHMIC study"],"pmcid":["PMC9792825"],"pubmed_authors":["Thomas de Montpreville V","Lacroix L","Scoazec J","Mercier O","Girard N","Saulnier P","Florez-Arango J","Lambotte O","Benitez J","Arana R","Molina T","Job B","Mussot S","Besse B","Fadel E"],"additional_accession":[]},"is_claimable":false,"name":"AB008. Activated pathways of Thymic Epithelial Tumors: a RYTHMIC study","description":"<h4>Background</h4> Thymic epithelial tumors (TETs) are rare malignancies of the anterior mediastinum with a high histopathological diversity from thymoma A to thymic carcinoma (TC). The biology of TETs is poorly understood and knowledge of the transcriptomic fingerprint of thymoma and TC is limited. Up to 30% of patients will develop associated autoimmune disorders, mainly myasthenia gravis (MG). We aimed to characterize main cancer activation pathways of TET subgroups. <h4>Methods</h4> We selected a representative balanced set of thymoma and TCs to analyze 24 main cancer activation pathways using gene expression throughout Oncology biomarker panel (2,562 genes). Tumor representative paraffin-embedded blocks were macrodissected. Then, we merged data with The Cancer Genome Atlas (TCGA) dat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-22T18:00:40.092Z","creation":"2025-04-06T02:20:11.905Z"},"accession":"S-EPMC9792825","cross_references":{}}